Evidence map›Paper›PMID 33340539›Full record

ArticleAnalytical biochemistry2021

Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet.

Andrea Arias-Alvarado, Mirjavid Aghayev, Serguei Ilchenko, Nadia Rachdaoui, Josephine Lepp, Tsung-Heng Tsai, Guo-Fang Zhang, Stephen Previs, Takhar Kasumov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Inhibition of Acetylation Activity of p300/CBP Ameliorates Hepatic Steatosis Through Downregulation of ACSL4.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  2. Article
  3. Article
  4. The role of acetylation in obesity-induced cardiac metabolic alterations.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Andrea Arias-AlvaradoDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Mirjavid AghayevDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Serguei IlchenkoDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Nadia RachdaouiDepartment of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA.
Josephine LeppDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Tsung-Heng TsaiDepartment of Mathematical Sciences, Kent State University, Kent, OH, 44242, USA.
Guo-Fang ZhangDivision of Division of Endocrinology, Metabolism and Nutrition, Duke Molecular Physiology Institute, And Department of Medicine, Duke University, Durham, NC, 27701, USA.
Stephen PrevisMerck & Co., Inc, 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.
Takhar KasumovDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA; Departments of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA. Electronic address: tkasumov@neomed.edu.
Northeast Ohio Medical University · USCleveland Clinic · USDuke University · USKent State University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USRutgers, The State University of New Jersey · US

Funding

NIDDK Network Coordinating UnitU24DK097771 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shuibing Chen, Jeffrey S. Grethe · 2013 to 2026
$20.9M
Follistatin-like protein 1 in cardiac and systemic metabolismR01HL129120 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RECCHIA, FABIO A, WALSH, KENNETH · 2016 to 2019
$2.9M
Novel computational methods for in vivo proteome dynamics estimation using heavy water metabolic labeling and LC-MSR01GM112044 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SADYGOV, ROVSHAN G · 2015 to 2023
$2.7M
Mitochondrial Proteome Dynamics in Heart Failure Assessed with Heavy WaterR21HL114407 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI KASUMOV, TAKHAR · 2012 to 2013
$394k
NHLBI NIH HHS R01 HL129120NHLBI NIH HHS R21 HL114407NIDDK NIH HHS U24 DK097771NIGMS NIH HHS R01 GM112044
6 · The paper itself

Abstract

Cellular availability of acetyl-CoA, a central intermediate of metabolism, regulates histone acetylation. The impact of a high-fat diet (HFD) on the turnover rates of acetyl-CoA and acetylated histones is unknown. We developed a method for simultaneous measurement of acetyl-CoA and acetylated histones kinetics using a single

Indexed as

AcetylationAcetyl Coenzyme AAnimalsDeuterium OxideDiet, High-FatHistonesHumansLiverLysineMaleMass SpectrometryMiceNon-alcoholic Fatty Liver DiseaseProtein Processing, Post-TranslationalAcetyl Coenzyme ADeuterium OxideHistonesLysineAcetylationAcetyl-CoAHeavy waterHigh resolution mass spectrometryHistoneTurnover

Identifiers

PMID33340539
PMCPMC13044785
OpenAlexW3110762378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.