ArticleCell host & microbe2021
The immune landscape in tuberculosis reveals populations linked to disease and latency.
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Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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129citing papers in PubMed
2.5field-weighted citation impact, top 6% of its field
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Who cites it
129 citing papers in PubMed, 193 citations in OpenAlex.
- Host-pathogen interactions in tuberculosis: from immunological mechanisms to translational applications.Cell insight · 2026Review
- Early immune dysregulation iniScience · 2026Article
- Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Airway immune signatures of protection and disease progression in recent human tuberculosis household contacts.Nature immunology · 2026Article
- The study of immunological markers in tuberculosis across animal models and its translation to human research.Lab animal · 2026Review
- Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.Cell reports. Medicine · 2026Article
- Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis.Mucosal immunology · 2026Article
- The host immune response to Mycobacterium tuberculosis determining protection or disease progression.Nature immunology · 2026Review
- Neutrophils repurpose the nucleolus as a cytokine reservoir and secretory organelle.bioRxiv : the preprint server for biology · 2026Article
- IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control.Nature communications · 2026Article
- Single-cell dissection of pleural and systemic immunity uncovers pathogen-specific immune reprogramming in tuberculosis versus lung adenocarcinoma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- A Rapid Active-Latent-Relapse Murine Model of Tuberculosis Based Blood Transcriptional Signature That Distinguishes Disease Stages.International journal of molecular sciences · 2026Article
- Type I interferons in tuberculosis pathogenesis and prevention.Trends in microbiology · 2026Review
- Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy.The Journal of infectious diseases · 2026Review
- Membrane atg8ylation and autophagy in protection against Mycobacterium tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Article
- Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis.bioRxiv : the preprint server for biology · 2026Article
- Functional analysis of distinct factors linked to the development of latent to active tuberculosis.Frontiers in cellular and infection microbiology · 2026Review
- Machine learning-based feature selection suggests circulating proteins as best at predicting and diagnosing tuberculosis inFrontiers in cellular and infection microbiology · 2026Article
- Article
69 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 6 institutions in 2 countries.
Ekaterina EsaulovaDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Shibali DasDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dhiraj Kumar SinghSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Jose Alberto Choreño-ParraLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City 14080, Mexico; Laboratorio de Inmunoquímica I, Posgrado en Ciencias Quimicobiológicas, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 07320, Mexico.
Amanda SwainDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Laura ArthurDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Javier Rangel-MorenoDepartment of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Mushtaq AhmedDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bindu SinghSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Ananya GuptaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Luis Alejandro Fernández-LópezLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City 14080, Mexico; Laboratorio de Inmunoquímica I, Posgrado en Ciencias Quimicobiológicas, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 07320, Mexico.
Maria de la Luz Garcia-HernandezDepartment of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Allison BucsanTulane National Primate Research Center, Tulane University School of Medicine, Covington 70112, Louisiana.
Chivonne MoodleyTulane National Primate Research Center, Tulane University School of Medicine, Covington 70112, Louisiana.
Smriti MehraTulane National Primate Research Center, Tulane University School of Medicine, Covington 70112, Louisiana.
Ethel García-LatorreLaboratorio de Inmunoquímica I, Posgrado en Ciencias Quimicobiológicas, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 07320, Mexico.
Joaquin ZunigaLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas," Mexico City 14080, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City 07320 Mexico.
Jeffrey AtkinsonDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Deepak KaushalSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA. Electronic address: dkaushal@txbiomed.org.
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: martyomov@wustl.edu.
Shabaana A KhaderDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: sakhader@wustl.edu.
Washington University in St. Louis · USTexas Biomedical Research Institute · USTulane University · USInstituto Nacional de Enfermedades Respiratorias · MXInstituto Politécnico Nacional · MXUniversity of Rochester Medical Center · US
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MThe Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7MViral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Deepak Kaushal, Kathryn Shelton · 2012 to 2026
$35.6MUniversiity of Rochester Center for Medical Countermeasures against RadiationU19AI091036 · NIAID · UNIVERSITY OF ROCHESTER · PI CHEN, YUHCHYAU · 2010 to 2014
$15.6MROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1MSocial stress as a co-morbidity of age-associated tuberculosisP01AG051428 · NIA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI TORRELLES, JORDI B · 2016 to 2020
$9.9MROLE OF IL-17 IN PROTECTIVE VACCINE-INDUCED IMMUNE RESPONSES AGAINST TUBERCULOSISR01HL105427 · NHLBI · WASHINGTON UNIVERSITY · PI KHADER, SHABAANA A. · 2011 to 2025
$5.9MImmune Correlates of Protection from TBR01AI134240 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2017 to 2022
$4.8MThe Role of Group 3 Innate Lymphoid cells (ILC3) in TuberculosisR01AI134236 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, KHADER, SHABAANA A. · 2017 to 2021
$4.4MUnderstanding the functional role of Myeloid Derived Suppressor cells in tuberculosisR01AI155024 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2020 to 2024
$4.1MPerturbation of antigen-specific T cell responses in latent TB/SIV co-infectionR01AI111943 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2015 to 2019
$3.9MCOMMON IMMUNE CORRELATES OF RISK OF TB DISEASE IN ANIMAL MODELS AND HUMANSR01AI123780 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2016 to 2019
$2.9MNHLBI NIH HHS R01 HL105427NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI111943NIAID NIH HHS R01 AI123780NIAID NIH HHS R01 AI134236NIAID NIH HHS R01 AI134240NIAID NIH HHS R01 AI155024NIAID NIH HHS U19 AI091036NIA NIH HHS P01 AG051428NIH HHS P51 OD011104NIH HHS P51 OD011133NIH HHS S10 OD028732NIH HHS U42 OD010442
Abstract
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects approximately one-fourth of the world's population. The immune mechanisms that govern progression from latent (LTBI) to active pulmonary TB (PTB) remain poorly defined. Experimentally Mtb-infected non-human primates (NHP) mirror the disease observed in humans and recapitulate both PTB and LTBI. We characterized the lung immune landscape in NHPs with LTBI and PTB using high-throughput technologies. Three defining features of PTB in macaque lungs include the influx of plasmacytoid dendritic cells (pDCs), an Interferon (IFN)-responsive macrophage population, and activated T cell responses. In contrast, a CD27
Indexed as
AnimalsDendritic CellsHumansKiller Cells, NaturalLatent TuberculosisLungMacaca mulattaMacrophagesMycobacterium tuberculosisTuberculosis, Pulmonarygranulomasimmune protectionlungNK cellspDCssingle cell technologiestuberculosistype I IFNs
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.