Evidence map›Paper›PMID 33340448›Full record

ArticleNeuron2021

Continuous Whole-Body 3D Kinematic Recordings across the Rodent Behavioral Repertoire.

Jesse D Marshall, Diego E Aldarondo, Timothy W Dunn, William L Wang, Gordon J Berman, Bence P Ölveczky

Abstract read
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. A spinal substrate for modular control of natural behavior.bioRxiv : the preprint server for biology · 2026
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  17. Cortex-Wide Substrates for Body Schema and Action Awareness.bioRxiv : the preprint server for biology · 2025
    Article
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  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jesse D MarshallDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: jesse_d_marshall@fas.harvard.edu.
Diego E AldarondoProgram in Neuroscience, Harvard University, Cambridge, MA 02138, USA.
Timothy W DunnDepartment of Statistical Science, Duke University, Durham, NC 27710, USA.
William L WangDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Gordon J BermanDepartment of Biology, Emory University, Atlanta, GA 30322, USA.
Bence P ÖlveczkyDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: olveczky@fas.harvard.edu.

Funding

Neural Circuits Underlying the Acquisition and Control of Motor SkillsR01NS099323 · NINDS · HARVARD UNIVERSITY · PI Bence P Olveczky · 2016 to 2026
$3.9M
CRCNS:Predictability as a New Paradigm for Rodent Social NeurobiologyR01MH115831 · NIMH · EMORY UNIVERSITY · PI BERMAN, GORDON JOSEPH, LIU, ROBERT C · 2017 to 2021
$2.2M
Neural and computational mechanisms underlying the assembly of motor skillsK99NS112597 · NINDS · HARVARD UNIVERSITY · PI MARSHALL, JESSE D. · 2019 to 2021
$326k
NINDS NIH HHS K99 NS112597NINDS NIH HHS R01 NS099323
6 · The paper itself

Abstract

In mammalian animal models, high-resolution kinematic tracking is restricted to brief sessions in constrained environments, limiting our ability to probe naturalistic behaviors and their neural underpinnings. To address this, we developed CAPTURE (Continuous Appendicular and Postural Tracking Using Retroreflector Embedding), a behavioral monitoring system that combines motion capture and deep learning to continuously track the 3D kinematics of a rat's head, trunk, and limbs for week-long timescales in freely behaving animals. CAPTURE realizes 10- to 100-fold gains in precision and robustness compared with existing convolutional network approaches to behavioral tracking. We demonstrate CAPTURE's ability to comprehensively profile the kinematics and sequential organization of natural rodent behavior, its variation across individuals, and its perturbation by drugs and disease, including identifying perseverative grooming states in a rat model of fragile X syndrome. CAPTURE significantly expands the range of behaviors and contexts that can be quantitatively investigated, opening the door to a new understanding of natural behavior and its neural basis.

Indexed as

AnimalsBehavior, AnimalBiomechanical PhenomenaGroomingMovementRatsanimal trackingautismbehaviorcomputational ethologygroomingindividualitymotion capturephenotyping

Identifiers

PMID33340448
PMCPMC7864892

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.