Evidence map›Paper›PMID 33340447›Full record

ArticleFEBS open bio2021

Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H

Xiujun Deng, Xinghuan Liang, Haiyan Yang, Zhenxing Huang, Xuemei Huang, Chunfeng Liang, Yaqi Kuang, Yingfen Qin, Faquan Lin, Zuojie Luo

Open access · goldAbstract read
In one paragraph

Article in FEBS open bio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Nicotinamide mononucleotide alleviates the streptozotocin-mediated ferroptosis of islet β-cells via the Nrf2/GPX4 pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  3. Review
  4. Article
  5. Molecules (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Article
  8. Physiological and Pathological Remodeling of Cerebral Microvessels.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiujun DengDepartment of Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xinghuan LiangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Haiyan YangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhenxing HuangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xuemei HuangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.ORCID 0000-0002-1883-9731
Chunfeng LiangDepartment of Blood transfusion, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yaqi KuangDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yingfen QinDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Faquan LinDepartment of Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zuojie LuoDepartment of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing number of studies have shown that nicotinamide mononucleotide (NMN) can inhibit not only ageing but also oxidative stress and inflammatory reactions by improving energy metabolism. However, the role of NMN in regulating the anti-apoptotic, antioxidative stress and inflammatory responses of brain microvascular endothelial cells is still unknown. Therefore, here we studied the effects of NMN on H

Indexed as

AnimalsApoptosisCell LineCytokinesHumansHydrogen PeroxideMiceNicotinamide MononucleotideNicotinamide PhosphoribosyltransferaseNitric Oxide Synthase Type IIIOxidative StressSignal TransductionTranscription Factor RelAVascular Endothelial Growth Factor ACytokinesHydrogen PeroxideNicotinamide MononucleotideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanNitric Oxide Synthase Type IIINOS3 protein, humanRELA protein, humanTranscription Factor RelAVascular Endothelial Growth Factor AVEGFA protein, humanbrain microvascular endothelial cellsinflammatory pathwaynicotinamide mononucleotidenicotinamide phosphoribosyltransferaseoxidative stress

Identifiers

PMID33340447
PMCPMC7931234
OpenAlexW3115694093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.