Evidence map›Paper›PMID 33340251›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2021

Microvascular changes at different stages of chronic kidney disease.

Dennis Kannenkeril, Shaun Frost, Janis M Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Justine Chan, Anu Joyson, Vance B Matthews, Lakshini Y Herat and 5 more

Abstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. When in doubt, pig it out: a versatile translational platform to study CKD, HFpEF, and CKM syndrome.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  5. Article
  6. Review
  7. Radiographic Imaging in Autosomal Dominant Polycystic Kidney Disease: A Claims Analysis.International journal of nephrology and renovascular disease · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dennis KannenkerilDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Shaun FrostCommonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, Australia.
Janis M NoldeDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.ORCID 0000-0001-6864-8514
Márcio Galindo KiuchiDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Revathy CarnagarinDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Leslie Marisol Lugo-GavidiaDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Justine ChanDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Anu JoysonDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Vance B MatthewsDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Lakshini Y HeratDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Omar AzzamDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.
Maryam MehdizadehCommonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, Australia.
Janardhan VignarajanCommonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, Australia.
Yogesan KanagasingamCommonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, Australia.
Markus P SchlaichDobney Hypertension Centre, School of Medicine - Royal Perth Hospital Unit / Medical Research Foundation, University of Western Australia, Perth, WA, Australia.ORCID 0000-0002-1765-0195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio- and cerebrovascular events than progressing to end-stage renal disease. The authors explored whether retinal microvascular calibers differed with the degree of renal impairment and between the standard and extended optic disk and may serve as a simple additional tool for risk stratification in this highly vulnerable patient cohort. The authors analyzed central retinal arteriolar and venular equivalent calibers (CRAE, CRVE) at different retinal zones (zone B&C) using digital retinal imaging in hypertensive patients with stage 2 (n = 66) or stage 3 CKD (n = 30). Results were adjusted for age, sex, HbA1c, and 24-hour diastolic blood pressure. Mean eGFR was 77.7 ± 8.9 and 48.8 ± 7.9 ml/min/1.73 m

Indexed as

HypertensionRenal Insufficiency, ChronicArteriolesGlomerular Filtration RateHumansRetinal Vesselschronic kidney diseaseglomerular filtration ratemicrovascular changeretinal vessel caliber hypertension sympathetic nervous system

Identifiers

PMID33340251
PMCPMC8029790

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.