Trial reportMedicina oral, patologia oral y cirugia bucal2021
Photobiomodulation therapy reduces postoperative pain after third molar extractions: A randomized clinical trial.
Trial report in Medicina oral, patologia oral y cirugia bucal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05344222 (Effects of Photobiomodulation Conditioning of Orofacial Tissue in Surgery for Removal of Impacted Mandibular Third Molars), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Photobiomodulation Conditioning of Orofacial Tissue in Surgery for Removal of Impacted Mandibular Third Molars: Randomized, Sham-controlled, Double-blind Clinical Trial
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis.Frontiers in oral health · 2024Pooled it
- Evaluation of local and systemic photobiomodulation in only single-implant insertion: a randomized clinical trial.Oral and maxillofacial surgery · 2025Trial
- Analgesic outcomes of 650 nm versus 810 nm diode laser photobiomodulation after dental implant placement in a randomized controlled trial.Scientific reports · 2026Article
- Patient reported pain following tooth extraction with different autologous platelet concentrates. Systematic review.BDJ open · 2025Article
- Laser-Mediated Hemostasis for Older Patients Receiving Routine Dental Treatment.Dentistry journal · 2025Article
- Clinical Study of Biostimulation with Low-Power Diode Laser After Dental Extractions.Clinics and practice · 2025Article
- The Effect of Photobiomodulation on Third Molar Wound Recovery: A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2024Review
- A novel investigational preclinical model to assess fluence rate for dental oral craniofacial tissues.Photodiagnosis and photodynamic therapy · 2024Article
- Photobiomodulation in dental extraction therapy: Postsurgical pain reduction and wound healing.Journal of the American Dental Association (1939) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the efficacy of PBMT on reducing postoperative pain scores in patients submitted to third molar extractions. MATERIAL AND
methodsA randomized controlled trial (ReBEC:RBR-94BCKZ) was designed according to the SPIRIT and followed the CONSORT. Patients were randomly allocated according to control or PBMT groups. PBMT consisted of the application of GaAlAs laser (808nm;50mW) applied in six points (1.23 min;11 J/cm2) after extraction. Pain scores were assessed using the Visual Analogue Scale (VAS) in millimeters evaluated after 6 (T6), 24 (T24), and 48 (T48) hours. The Wilcoxon Mann-Whitney test was used to check for possible associations between VAS scores and treatment groups.
resultsA total of 101 third molar extractions were performed in 44 patients. The mean age was 28 years old(SD±11.54). Comparing control and intervention, PBMT group showed a significant effect on the reduction of postoperative pain at T6(mean VAS=0.9; C.I:0.63-1.16) compared to control (mean VAS=2.5;C.I:2.1-2.88)(p<0.001). The same statistically significant effect on the reduction of postoperative pain was observed at T24 (PBMT mean VAS=0.72;C.I:0.51-0.93; control mean VAS=2.86;C.I:2.40-3.31;p<0.001) and T48 (PBMT mean VAS=0.64;C.I:0.36-0.92; control mean VAS=2.86;C.I:2.37-3.34;p<0.001).
conclusionsPBMT significantly reduce the postoperative pain scores when assessed 6, 24, and 48 hours after third molar extractions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.