Evidence map›Paper›PMID 33339532›Full record

ArticleAlzheimer's research & therapy2020

Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study.

Susanne Röhr, Alexander Pabst, Steffi G Riedel-Heller, Frank Jessen, Yuda Turana, Yvonne S Handajani, Carol Brayne, Fiona E Matthews, Blossom C M Stephan, Richard B Lipton and 40 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 6 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Pooled it
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  16. Mandarin speech-based early detection of SCD: a feature-fusion residual network method.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  18. Observational
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors at 20 institutions in 15 countries.

Susanne RöhrInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany. susanne.roehr@medizin.uni-leipzig.de.ORCID 0000-0001-9385-0669
Alexander PabstInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany.
Steffi G Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany.
Frank JessenDepartment of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.
Yuda TuranaDepartment of Neurology, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Yvonne S HandajaniCenter for Health Research, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Carol BrayneCambridge Public Health, Cambridge University, Cambridge, UK.
Fiona E MatthewsMRC Biostatistics Unit, Institute of Public Health, Cambridge University, Cambridge, UK.
Blossom C M StephanInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Richard B LiptonSaul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.
Mindy J KatzSaul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.
Cuiling WangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.
Maëlenn GuerchetINSERM, U1094, Tropical Neuroepidemiology, Limoges, France.
Pierre-Marie PreuxINSERM, U1094, Tropical Neuroepidemiology, Limoges, France.
Pascal MbelessoINSERM, U1094, Tropical Neuroepidemiology, Limoges, France.
Karen RitchieINSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier, Montpellier, France.
Marie-Laure AncelinINSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier, Montpellier, France.
Isabelle CarrièreINSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier, Montpellier, France.
Antonio GuaitaGolgi Cenci Foundation, Corso San Martino 10, 20081, Abbiategrasso, Italy.
Annalisa DavinGolgi Cenci Foundation, Corso San Martino 10, 20081, Abbiategrasso, Italy.
Roberta VaccaroGolgi Cenci Foundation, Corso San Martino 10, 20081, Abbiategrasso, Italy.
Ki Woong KimDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Ji Won HanDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Seung Wan SuhDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Suzana ShaharCentre of Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Normah C DinCentre for Rehabilitation Science and Special Needs, Faculty of Health Science, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Divya VanohSchool of Health Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Martin van BoxtelDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
Sebastian KöhlerDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.
Mary GanguliDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Erin P JacobsenDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Beth E SnitzDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kaarin J AnsteyAgeing Futures Institute, University of New South Wales, Sydney, NSW, Australia.
Nicolas CherbuinCentre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, Australian National University, Canberra, ACT, Australia.
Shuzo KumagaiCenter for Health Science and Counseling, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Sanmei ChenDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Kenji NarazakiFaculty of Socio-Environmental Studies, Department of Socio-Environmental Studies, Fukuoka Institute of Technology, 3-30-1 Wajiro-higashi, Higashi-ku, Fukuoka, 811-0295, Japan.
Tze Pin NgDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Qi GaoDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Xinyi GweeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Nicole A KochanCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Julian TrollorCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Antonio LoboCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain.
Raúl López-AntónCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain.
Javier SantabárbaraCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain.
John D CrawfordCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Darren M LipnickiCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
for Cohort Studies of Memory in an International Consortium (COSMIC)
Inserm · FRUNSW Sydney · AUAlbert Einstein College of Medicine · USFondazione Golgi Cenci · ITNational University of Singapore · SGUniversidad de Zaragoza · ESUniversity of Pittsburgh · USAtma Jaya Catholic University of Indonesia · IDAustralian National University · AUKyushu University · JPLeipzig University · DEMaastricht University · NLNational University of Malaysia · MYSeoul National University · KRUniversity of Cambridge · GBFukuoka Institute of Technology · JPHospital Universiti Sains Malaysia · MYNewcastle University · GBSeoul National University Bundang Hospital · KRTrinity College Dublin · IE

Funding

COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settingsRF1AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI SACHDEV, PERMINDER S · 2017 to 2020
$2.9M
Medical Research Council G0601022NIA NIH HHS RF1 AG057531NIA NIH HHS RF1AG057531
6 · The paper itself

Abstract

backgroundSubjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts.

methodsWe combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence.

resultsThe sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades.

conclusionsSCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.

Indexed as

Cognitive DysfunctionAgingCohort StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsPrevalenceCohort studyData harmonizationEpidemiologyIndividual participant dataPrevalenceSubjective cognitive decline

Identifiers

PMID33339532
PMCPMC7749505
OpenAlexW3112120242

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.