Evidence map›Paper›PMID 33339470›Full record

ArticleThe International journal of artificial organs2021

Interdialytic weight gain of less than 2.5% seems to limit cardiac damage during hemodialysis.

Junko Goto, Ulf Forsberg, Per Jonsson, Kenichi Matsuda, Bo Nilsson, Kristina Nilsson Ekdahl, Michael Y Henein, Bernd G Stegmayr

Registry-linked trialAbstract read
In one paragraph

Article in The International journal of artificial organs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06153888 (The Effect of Hemodialysis on proBNP), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06153888 narecruitingnot on this mapstarted 2023, after this paper: background citation

The Effect of Hemodialysis on proBNP

TypeinterventionalSponsorUmeå UniversityRan2023 to 2026Enrolled40ConditionsFluid Overload, Dialysis, ComplicationsArmsUltrafiltration rate
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junko GotoInstitute of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden.
Ulf ForsbergInstitute of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden.
Per JonssonInstitute of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden.
Kenichi MatsudaDepartment of Emergency and Critical Care Medicine, School of Medicine, University of Yamanashi, Yamanashi, Japan.
Bo NilssonDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Kristina Nilsson EkdahlDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Michael Y HeneinInstitute of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden.
Bernd G StegmayrInstitute of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0003-2694-7035

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate if a single low-flux HD induces a rise in cardiac biomarkers and if a change in clinical approach may limit such mechanism. MATERIAL AND

methodsA total of 20 chronic HD patients each underwent three different study-dialyses. Dialyzers (low-flux polysulfone, 1.8 sqm) had been stored either dry or wet (Wet) and the blood level in the venous chamber kept low or high. Laboratory results were measured at baseline, 30 and 180 min, adjusted for the effect of fluid shift. Ultrasound measured microemboli signals (MES) within the return line.

resultsHemodialysis raised cardiac biomarkers (

conclusionHemodialysis, independent of type of dialyzer storage, was associated with raised cardiac biomarkers, more profoundly in patients with higher pre-dialysis values and IDWG. A limitation in IDWG to <2.5% and prolonged ultrafiltration time may limit cardiac strain during HD, especially in patients with cardiovascular risk.

Indexed as

Kidney Failure, ChronicBiomarkersHumansRenal DialysisWeight GainBiomarkersBiocompatibilityembolihearthemodialysisinterdialytic weight gainNT-pro-BNPpentraxintroponin

Identifiers

PMID33339470
PMCPMC8366174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.