Evidence map›Paper›PMID 33339452›Full record

ArticlePharmaceutics2020

Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications.

Lara S Costard, Domhnall C Kelly, Rachael N Power, Christopher Hobbs, Sonia Jaskaniec, Valeria Nicolosi, Brenton L Cavanagh, Caroline M Curtin, Fergal J O'Brien

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lara S CostardTissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), 123 St Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0001-9717-6616
Domhnall C KellyTissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), 123 St Stephen's Green, D02 YN77 Dublin, Ireland.
Rachael N PowerTissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), 123 St Stephen's Green, D02 YN77 Dublin, Ireland.
Christopher HobbsAdvanced Materials and Bioengineering Research Centre (AMBER), RCSI and Trinity College Dublin (TCD), College Green, D02 PN40 Dublin, Ireland.
Sonia JaskaniecAdvanced Materials and Bioengineering Research Centre (AMBER), RCSI and Trinity College Dublin (TCD), College Green, D02 PN40 Dublin, Ireland.ORCID 0000-0003-1915-8759
Valeria NicolosiAdvanced Materials and Bioengineering Research Centre (AMBER), RCSI and Trinity College Dublin (TCD), College Green, D02 PN40 Dublin, Ireland.
Brenton L CavanaghCellular and Molecular Imaging Core, RCSI, 123 St Stephen's Green, D02 YN77 Dublin, Ireland.
Caroline M CurtinTissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), 123 St Stephen's Green, D02 YN77 Dublin, Ireland.
Fergal J O'BrienTissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), 123 St Stephen's Green, D02 YN77 Dublin, Ireland.ORCID 0000-0003-2030-8005

Funding

Centre for Advanced Materials and Bioengineering Research (AMBER) SFI/12/RC/2278 and SFI/12/RC/2278_P2Health Research Board ILP-POR-2017-032Irish Research Council Government of Ireland Postgraduate Programme GOIPG/2018/371Science Foundation Ireland 13/RC/2073
6 · The paper itself

Abstract

Nonviral vectors offer a safe alternative to viral vectors for gene therapy applications, albeit typically exhibiting lower transfection efficiencies. As a result, there remains a significant need for the development of a nonviral delivery system with low cytotoxicity and high transfection efficacy as a tool for safe and transient gene delivery. This study assesses MgAl-NO

Indexed as

biomaterialsdrug deliverygene therapylayered double hydroxidemicroRNAnonviral vectorplasmid DNAscaffoldsiRNA

Identifiers

PMID33339452
PMCPMC7765978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.