Evidence map›Paper›PMID 33339436›Full record

ReviewJournal of clinical medicine2020

Experience in Multiple Sclerosis Patients with COVID-19 and Disease-Modifying Therapies: A Review of 873 Published Cases.

Nora Möhn, Franz F Konen, Refik Pul, Christoph Kleinschnitz, Harald Prüss, Torsten Witte, Martin Stangel, Thomas Skripuletz

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04796584 terminatednot on this mapstarted 2022, after this paper: background citation

Efficacy of COVID 19 SARS-CoV-2 mRNA Vaccination in Patients With Multiple Sclerosis Treated With Immune Modulating Medication (SARSmRNA_MS)

TypeobservationalSponsorProvidence Health & ServicesRan2022 to 2022Enrolled20ConditionsMultiple SclerosisArmsAnalysis of cell-mediated and antibody-mediated immunity to SARS-CoV-2 virus
NCT05081271 early_phase1terminatednot on this mapstarted 2021, after this paper: background citation

COVID-19 Booster Vaccination in Persons With Multiple Sclerosis

TypeinterventionalSponsorGriffin HospitalRan2021 to 2022Enrolled10ConditionsMultiple SclerosisArmsHomologous booster, Heterologous booster
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. The influence of the COVID-19 pandemic on the prescription of multiple sclerosis medication in Germany.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Humoral immune response after COVID-19 in multiple sclerosis: A nation-wide Austrian study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021
    Article
  20. Vaccination and multiple sclerosis in the era of the COVID-19 pandemic.Journal of neurology, neurosurgery, and psychiatry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nora MöhnDepartment of Neurology, Hanover Medical School, 30625 Hannover, Germany.
Franz F KonenDepartment of Neurology, Hanover Medical School, 30625 Hannover, Germany.
Refik PulDepartment of Neurology, University Hospital Essen, 45147 Essen, Germany.
Christoph KleinschnitzDepartment of Neurology, University Hospital Essen, 45147 Essen, Germany.
Harald PrüssDepartment of Neurology and Experimental Neurology, Charité Universitätsmedizin Berlin and German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
Torsten WitteDepartment of Rheumatology & Immunology, Hannover Medical School, 30625 Hannover, Germany.
Martin StangelDepartment of Neurology, Hanover Medical School, 30625 Hannover, Germany.
Thomas SkripuletzDepartment of Neurology, Hanover Medical School, 30625 Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a challenge for all participants in the healthcare system. At the beginning of the pandemic, many physicians asked themselves what risk their patients, especially those with chronic diseases, were exposed to. We present an overview of all patients with multiple sclerosis (MS) and SARS-CoV-2 infection published in the literature so far. In total, there are publications on 873 SARS-CoV-2 positive MS patients and information on the outcome can be given for 700 patients. With regard to the different disease modifying therapies (DMTs), by far the most cases were described under anti-CD20 treatment (

Indexed as

COVID-19disease-modifying therapiesmultiple sclerosisSARS-CoV-2 pandemic

Identifiers

PMID33339436
PMCPMC7766122

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.