Evidence map›Paper›PMID 33339254›Full record

ArticleAntioxidants (Basel, Switzerland)2020

Spontaneous Formation of Melanin from Dopamine in the Presence of Iron.

David M Hedges, Jordan T Yorgason, Andrew W Perez, Nathan D Schilaty, Benjamin M Williams, Richard K Watt, Scott C Steffensen

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Theoretical Studies of Cyanophycin Dipeptides as Inhibitors of Tyrosinases.International journal of molecular sciences · 2022
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

David M HedgesEnterprise Information Management, Billings Clinic, 2800 10th Avenue North, Billings, MT 59101, USA.
Jordan T YorgasonDepartment of Physiology and Developmental Biology, 4005 LSB, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0002-5687-0676
Andrew W PerezNeuroscience Program, S-192 ESC, Brigham Young University, Provo, UT 84602, USA.
Nathan D SchilatyNeuroscience Program, S-192 ESC, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0002-6038-7126
Benjamin M WilliamsNeuroscience Program, S-192 ESC, Brigham Young University, Provo, UT 84602, USA.
Richard K WattDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT 84602, USA.
Scott C SteffensenNeuroscience Program, S-192 ESC, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0001-6463-8861
Brigham Young University · US

Funding

Nicotine and Alcohol Co-DependenceR01DA035958 · NIDA · BRIGHAM YOUNG UNIVERSITY · PI STEFFENSEN, SCOTT C · 2014 to 2018
$2.0M
NIDA NIH HHS R01 DA035958NIH HHS AA020919NIH HHS DA035958
6 · The paper itself

Abstract

Parkinson's disease is associated with degeneration of neuromelanin (NM)-containing substantia nigra dopamine (DA) neurons and subsequent decreases in striatal DA transmission. Dopamine spontaneously forms a melanin through a process called melanogenesis. The present study examines conditions that promote/prevent DA melanogenesis. The kinetics, intermediates, and products of DA conversion to melanin in vitro, and DA melanogenesis under varying levels of Fe

Indexed as

dopamineironmelaninneuromelaninoxidative stress

Identifiers

PMID33339254
PMCPMC7766172
OpenAlexW3113279644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.