Evidence map›Paper›PMID 33339213›Full record

ReviewJournal of cardiovascular development and disease2020

Biology and Biomechanics of the Heart Valve Extracellular Matrix.

Karthik M Kodigepalli, Kaitlyn Thatcher, Toni West, Daniel P Howsmon, Frederick J Schoen, Michael S Sacks, Christopher K Breuer, Joy Lincoln

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 88 citations in OpenAlex.

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  20. Murine Aortic Valve Cell Heterogeneity at Birth.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Karthik M KodigepalliDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Kaitlyn ThatcherDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Toni WestCenter for Cardiovascular Simulation, Institute for Computational Engineering and Sciences and Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-7665-1860
Daniel P HowsmonCenter for Cardiovascular Simulation, Institute for Computational Engineering and Sciences and Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-7177-1342
Frederick J SchoenDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Michael S SacksCenter for Cardiovascular Simulation, Institute for Computational Engineering and Sciences and Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-3199-2204
Christopher K BreuerTissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Joy LincolnDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-1517-6888
The University of Texas at Austin · USMedical College of Wisconsin · USBrigham and Women's Hospital · USChildren's Hospital of Wisconsin · USNationwide Children's Hospital · US

Funding

Advancing a Healthier Wisconsin 5520519Moss Foundation N/ANational Institute of Health R01HL073021National Institute of Health R01HL128847National Institute of Health R01HL142504National Institute of Health R01HL142685
6 · The paper itself

Abstract

Heart valves are dynamic structures that, in the average human, open and close over 100,000 times per day, and 3 × 10

Indexed as

collagenconnective tissue disorderselastinextracellular matrixheart valveproteoglycan

Identifiers

PMID33339213
PMCPMC7765611
OpenAlexW3110976917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.