Evidence map›Paper›PMID 33339211›Full record

ReviewCells2020

Human Tissue-Resident Memory T Cells in the Maternal-Fetal Interface. Lost Soldiers or Special Forces?

Caitlin S DeJong, Nicholas J Maurice, Stephen A McCartney, Martin Prlic

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05473273 (Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05473273 recruitingnot on this mapstarted 2023, after this paper: background citation

Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle (NC).

TypeobservationalSponsorART Fertility Clinics LLCRan2023 to 2026Enrolled40ConditionsInfertility, FemaleArmsEndometrin 100Mg Vaginal Insert, Estradiol Valerate
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  2. Article
  3. Pregnancy-acquired memory CD4Nature communications · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Caitlin S DeJongVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.ORCID 0000-0002-5714-0077
Nicholas J MauriceVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.ORCID 0000-0002-2667-472X
Stephen A McCartneyDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-1102-6778
Martin PrlicVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
University of Washington · USFred Hutch Cancer Center · US

Funding

NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Single-Cell Analysis To Define Protective and Tolerizing Immune Cell Populations in the Human PlacentaR21AI144677 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRLIC, MARTIN, SHREE, RAJ · 2020 to 2021
$570k
Investigating the Role of Dysregulated Immunity and Inflammation at the Maternal-Fetal Interface in PreeclampsiaF31HD098769 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MAURICE, NICHOLAS JOSEPH · 2019 to 2019
$12k
NCATS NIH HHS TL1 TR002318NICHD NIH HHS F31 HD098769NIH HHS F31 HD098769NIH HHS R21 AI144677NIH HHS TL1 TR002318
6 · The paper itself

Abstract

The immune system plays a critical role during pregnancy, but the specific mechanisms and immune cell function needed to support pregnancy remain incompletely understood. Despite decades of research efforts, it is still unclear how the immune system maintains tolerance of fetal-derived tissues, which include most cells of the placenta and of course the fetus itself, without forfeiting the ability to protect against harmful infections. T cells recognize antigen in the context of major histocompatibility complex (MHC) encoded proteins, but classical MHC class I and II expression are diminished in fetal-derived cells. Can T cells present at the maternal-fetal interface (MFI) protect these cells from infection? Here we review what is known in regard to tissue-resident memory T (Trm) cells at the MFI. We mainly focus on how Trm cells can contribute to protection in the context of the unique features of the MFI, such as limited MHC expression as well as the temporary nature of the MFI, that are not found in other tissues.

Indexed as

Immunologic MemoryCell CompartmentationFemaleHumansLymphocyte SubsetsMaternal-Fetal ExchangeModels, BiologicalPregnancyT-Lymphocytesmaternal–fetal interfaceMHC class I/IIplacentatissue-resident memory T cells

Identifiers

PMID33339211
PMCPMC7765601
OpenAlexW3111923811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.