Evidence map›Paper›PMID 33339129›Full record

ArticleInternational journal of molecular sciences2020

Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like Characteristics.

Shiv Verma, Eswar Shankar, F Naz Cemre Kalayci, Amrita Mukunda, Malek Alassfar, Vaibhav Singh, E Ricky Chan, Gregory T MacLennan, Sanjay Gupta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

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  17. Prostate Cancer Stem Cells: Biology and Treatment Implications.International journal of molecular sciences · 2023
    Review
  18. A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer.Journal of experimental & clinical cancer research : CR · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Shiv VermaDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Eswar ShankarDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-8968-838X
F Naz Cemre KalayciThe Hacettepe University Medical Center, Hacettepe University, Sihhiye, Ankara 06100, Turkey.
Amrita MukundaKrieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Malek AlassfarDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Vaibhav SinghDepartment of Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
E Ricky ChanDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Gregory T MacLennanDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Sanjay GuptaDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-9492-3249
Case Western Reserve University · USUniversity Hospitals of Cleveland · USCleveland Clinic · USHacettepe University · TRJohns Hopkins University · US

Funding

U.S. Department of Defense W81XWH-18-1-0618U.S. Department of Defense W81XWH-19-1-0720U.S. Department of Veterans Affairs 1I01BX002494
6 · The paper itself

Abstract

Enzalutamide, an antiandrogen, is approved for therapy of castration resistant prostate cancer. Clinical applications have shown that approximately 30% of patients acquire resistance after a short period of treatment. However, the molecular mechanisms underlying this resistance is not completely understood. To identify transcriptomic signatures associated with acquisition of drug resistance we profiled gene expression of paired enzalutamide sensitive and resistant human prostate cancer LNCaP (lymph node carcinoma of the prostate) and C4-2B cells. Overlapping genes differentially regulated in the enzalutamide resistant cells were ranked by Ingenuity Pathway Analysis and their functional validation was performed using ingenuity knowledge database followed by confirmation to correlate transcript with protein expression. Analysis revealed that genes associated with cancer stem cells, such as

Indexed as

Gene Regulatory NetworksTranscriptomeAndrogen Receptor AntagonistsAndrogensBenzamidesCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleNeoplastic Stem CellsNitrilesPhenylthiohydantoinProstatic Neoplasms, Castration-ResistantAndrogen Receptor AntagonistsAndrogensBenzamidesenzalutamideNitrilesPhenylthiohydantoinantiandrogenscancer stem cellscastrate resistant prostate cancerenzalutamide resistancetranscriptional reprogramming

Identifiers

PMID33339129
PMCPMC7765584
OpenAlexW3113278707

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.