Evidence map›Paper›PMID 33339100›Full record

ArticlePolymers2020

Enzyme-Crosslinked Gelatin Hydrogel with Adipose-Derived Stem Cell Spheroid Facilitating Wound Repair in the Murine Burn Model.

Ting-Yu Lu, Kai-Fu Yu, Shuo-Hsiu Kuo, Nai-Chen Cheng, Er-Yuan Chuang, Jia-Shing Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ting-Yu LuDepartment of Chemical Engineering, College of Engineering, National Taiwan University, Taipei 10617, Taiwan.
Kai-Fu YuDepartment of Chemical Engineering, College of Engineering, National Taiwan University, Taipei 10617, Taiwan.
Shuo-Hsiu KuoDepartment of Chemical Engineering, College of Engineering, National Taiwan University, Taipei 10617, Taiwan.
Nai-Chen ChengDepartment of Surgery, National Taiwan University Hospital, Taipei 10617, Taiwan.
Er-Yuan ChuangInternational Ph.D. Program in Biomedical Engineering, Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Jia-Shing YuDepartment of Chemical Engineering, College of Engineering, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0002-0782-2328
National Taiwan University · TWNational Taiwan University Hospital · TWWan Fang Hospital · TW

Funding

Ministry of Science and Technology, Taiwan 109-2221-E-002-101
6 · The paper itself

Abstract

Engineered skin that can facilitate tissue repair has been a great advance in the field of wound healing. A well-designed dressing material together with active biological cues such as cells or growth factors can overcome the limitation of using auto-grafts from patients. Recently, many studies showed that human adipose-derived stem cells (hASCs) can be used to promote wound healing and skin tissue engineering. hASCs have already been widely applied for clinical trials. hASCs can be harvested abundantly because they can be easily isolated from fat tissue known as the stromal vascular fraction (SVF). On the other hand, increasing studies have proven that cells from spheroids can better simulate the biological microenvironment and can enhance the expression of stemness markers. However, a three-dimensional (3D) scaffold that can harbor implanted cells and can serve as a skin-repaired substitute still suffers from deficiency. In this study, we applied a gelatin/microbial transglutaminase (mTG) hydrogel to encapsulate hASC spheroids to evaluate the performance of 3D cells on skin wound healing. The results showed that the hydrogel is not toxic to the wound and that cell spheroids have significantly improved wound healing compared to cell suspension encapsulated in the hydrogel. Additionally, a hydrogel with cell spheroids was much more effective than other groups in angiogenesis since the cell spheroid has the possibility of cell-cell signaling to promote vascular generation.

Indexed as

cell spheroidgelatinhuman adipose-derived stem cellshydrogelwound healing

Identifiers

PMID33339100
PMCPMC7765510
OpenAlexW3112733634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.