ArticleActa biomaterialia2021
Right ventricular myocardial mechanics: Multi-modal deformation, microstructure, modeling, and comparison to the left ventricle.
Article in Acta biomaterialia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Constitutive discovery in the living human heart.bioRxiv : the preprint server for biology · 2026Article
- Detecting early structural and functional myocardial alterations in patients with repaired tetralogy of fallot: a prospective MRI study.Scientific reports · 2026Article
- Mechanical Modeling of Cardiac Fibrosis With Explicit Spatial Representation of Cellular Structure and Collagen Alignment.Journal of biomechanical engineering · 2026Article
- Discovering dispersion: How robust is automated model discovery for human myocardial tissue?Biomechanics and modeling in mechanobiology · 2025Article
- Quantifying HiPSC-CM structural organization at scale with deep learning-enhanced SarcGraph.PLoS computational biology · 2025Article
- Article
- Distinguishing shear and tensile myocardial wall stiffness using ex vivo anisotropic Magnetic Resonance Elastography.Acta biomaterialia · 2025Article
- Tricuspid valve edge-to-edge repair simulations are highly sensitive to annular boundary conditions.Journal of the mechanical behavior of biomedical materials · 2025Article
- Stress relaxation rates of myocardium from failing and non-failing hearts.Biomechanics and modeling in mechanobiology · 2025Article
- Generative Hyperelasticity with Physics-Informed Probabilistic Diffusion Fields.Engineering with computers · 2025Article
- How well do 3D-printed tissue mimics represent the complex mechanics of biological soft tissues? An example study with Stratasys' cardiovascular TissueMatrix materials.Journal of biomedical materials research. Part A · 2025Article
- An optimized differential evolution algorithm for constitutive model fitting of arteries.Acta mechanica · 2024Article
- Segmenting mechanically heterogeneous domains via unsupervised learning.Biomechanics and modeling in mechanobiology · 2024Article
- Untangling the mechanisms of pulmonary arterial hypertension-induced right ventricular stiffening in a large animal model.Acta biomaterialia · 2023Article
- AI-dente: an open machine learning based tool to interpret nano-indentation data of soft tissues and materials.Soft matter · 2023Article
- A multi-scale computational model for the passive mechanical behavior of right ventricular myocardium.Journal of the mechanical behavior of biomedical materials · 2023Article
- Untangling the mechanisms of pulmonary hypertension-induced right ventricular stiffening in a large animal model.bioRxiv : the preprint server for biology · 2023Article
- A cell-based framework for modeling cardiac mechanics.Biomechanics and modeling in mechanobiology · 2023Article
- Can machine learning accelerate soft material parameter identification from complex mechanical test data?Biomechanics and modeling in mechanobiology · 2023Article
- An introduction to the Ogden model in biomechanics: benefits, implementation tools and limitations.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The right ventricular myocardium, much like the rest of the right side of the heart, has been consistently understudied. Presently, little is known about its mechanics, its microstructure, and its constitutive behavior. In this work, we set out to provide the first data on the mechanics of the mature right ventricular myocardium in both simple shear and uniaxial loading and to compare these data to the mechanics of the left ventricular myocardium. To this end, we tested ovine tissue samples of the right and left ventricle under a comprehensive mechanical testing protocol that consisted of six simple shear modes and three tension/compression modes. After mechanical testing, we conducted a histology-based microstructural analysis on each right ventricular sample that yielded high resolution fiber distribution maps across the entire samples. Equipped with this detailed mechanical and histological data, we employed an inverse finite element framework to determine the optimal form and parameters for microstructure-based constitutive models. The results of our study show that right ventricular myocardium is less stiff then the left ventricular myocardium in the fiber direction, but similarly exhibits non-linear, anisotropic, and tension/compression asymmetric behavior with direction-dependent Poynting effect. In addition, we found that right ventricular myocardial fibers change angles transmurally and are dispersed within the sheet plane and normal to it. Through our inverse finite element analysis, we found that the Holzapfel model successfully fits these data, even when selectively informed by rudimentary microstructural information. And, we found that the inclusion of higher-fidelity microstructural data improved the Holzapfel model's predictive ability. Looking forward, this investigation is a critical step towards understanding the fundamental mechanical behavior of right ventricular myocardium and lays the groundwork for future whole-organ mechanical simulations.
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