ArticleNeuroImage2021
Dissociating harmonic and non-harmonic phase-amplitude coupling in the human brain.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- Spectrotemporal signatures of driving- and modulatory circuits across cortical and subcortical networks.Frontiers in human neuroscience · 2026Article
- Power-to-power cross-frequency coupling as a novel approach for temporal lobe seizure detection and analysis.Neuroscience informatics · 2025Article
- Musical neurodynamics.Nature reviews. Neuroscience · 2025Review
- The classification of absence seizures using power-to-power cross-frequency coupling analysis with a deep learning network.Frontiers in neuroinformatics · 2025Article
- The detection of absence seizures using cross-frequency coupling analysis with a deep learning network.Research square · 2024Article
- Article
- Review
- Direct modulation index: A measure of phase amplitude coupling for neurophysiology data.Human brain mapping · 2023Article
- Methodological considerations for studying neural oscillations.The European journal of neuroscience · 2022Article
- Understanding Harmonic Structures Through Instantaneous Frequency.IEEE open journal of signal processing · 2022Article
- Automatic decomposition of electrophysiological data into distinct nonsinusoidal oscillatory modes.Journal of neurophysiology · 2021Article
- Detecting Phase-Synchrony Connectivity Anomalies in EEG Signals. Application to Dyslexia Diagnosis.Sensors (Basel, Switzerland) · 2021Article
- Targeting neural oscillations with transcranial alternating current stimulation.Brain research · 2021Review
- Revealing the Dynamic Nature of Amplitude Modulated Neural Entrainment With Holo-Hilbert Spectral Analysis.Frontiers in neuroscience · 2021Article
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Authors and funding
3 authors.
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Abstract
Phase-amplitude coupling (PAC) has been hypothesized to coordinate cross-frequency interactions of neuronal activity in the brain. However, little is known about the distribution of PAC across the human brain and the frequencies involved. Furthermore, it remains unclear to what extent PAC may reflect spurious cross-frequency coupling induced by physiological artifacts or rhythmic non-sinusoidal signals with higher harmonics. Here, we combined MEG, source-reconstruction and different measures of cross-frequency coupling to systematically characterize local PAC across the resting human brain. We show that cross-frequency measures of phase-amplitude, phase-phase, and amplitude-amplitude coupling are all sensitive to signals with higher harmonics. In conjunction, these measures allow to distinguish harmonic and non-harmonic PAC. Based on these insights, we found no evidence for non-harmonic local PAC in resting-state MEG. Instead, we found cortically and spectrally wide-spread PAC driven by harmonic signals. Furthermore, we show how physiological artifacts and spectral leakage cause spurious PAC across wide frequency ranges. Our results clarify how different measures of cross-frequency interactions can be combined to characterize PAC, and cast doubt on the presence of prominent non-harmonic phase-amplitude coupling in human resting-state MEG.
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