ReviewMagnetic resonance imaging2021
MR cell size imaging with temporal diffusion spectroscopy.
Review in Magnetic resonance imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 47 citations in OpenAlex.
- Benign and Malignant Breast Lesions: Differentiation Using Microstructural Metrics Derived from Time-Dependent Diffusion MRI.Radiology. Imaging cancer · 2025Trial
- Time-dependent diffusion MRI for differentiating cervical cancer subtypes: impact of ROI delineation strategies on diagnostic performance.Abdominal radiology (New York) · 2026Article
- Feasibility of predicting breast cancer Ki-67 expression using histogram features derived from time-dependent diffusion magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- The role of diffusion-weighted MRI in biological image-guided radiation therapy: a roadmap.Physics in medicine and biology · 2026Review
- Improving the diagnostic efficacy of MR cytometry in prostate cancer imaging.Abdominal radiology (New York) · 2026Article
- The predictive value of MR cytometry in histological differentiation of rectal cancer: an exploratory study.European radiology · 2026Observational
- Time-dependent diffusion MRI for differentiating non‑small cell lung‑cancer brain metastases from breast‑cancer brain metastases and gliomas.Neuroradiology · 2026Article
- Development of Linear Interpolation System for SMK Model Parameters Evaluated from Cellular-Scale Simulation (LISMEC) and its application to BNCT dosimetry.Journal of radiation research · 2026Article
- Lymph Node Metastases Prediction in Cervical Cancer Using Time-Dependent Diffusion MRI and Macromolecular Proton Fraction Imaging.Radiology. Imaging cancer · 2026Article
- Repeatability of in vivo MR cytometry for measuring cell size and density in healthy human livers.Magnetic resonance imaging · 2026Article
- Comprehensive characterization of tumor therapeutic response via simultaneous mapping of cell size, density, and transcytolemmal water exchange.Magnetic resonance imaging · 2025Article
- MATI: A GPU-accelerated toolbox for microstructural diffusion MRI simulation and data fitting with a graphical user interface.Magnetic resonance imaging · 2025Article
- Comparison of MR cytometry methods in predicting immunohistochemical factor status and molecular subtypes of breast cancer.Radiology and oncology · 2025Article
- Quantitative Analysis With Time-Dependent Diffusion MRI for Assessing WHO/ISUP Tumor Grade in Clear Cell Renal Cell Carcinoma.Korean journal of radiology · 2025Article
- Influence of Multiband Technique on Temporal Diffusion Spectroscopy and Its Diagnostic Value in Breast Tumors.Journal of magnetic resonance imaging : JMRI · 2025Article
- Risk Stratification Prediction of Endometrial Cancer Using Microstructural Mapping Based on Time-Dependent Diffusion MRI.Cancer science · 2025Article
- Noninvasive assessment of liver inflammation in metabolic dysfunction associated steatohepatitis using MR cytometry.Npj imaging · 2025Article
- Distinguishing Hepatocellular Carcinoma from Cirrhotic Regenerative Nodules Using MR Cytometry.Cancers · 2025Article
- Artificial intelligence in fracture detection on radiographs: a literature review.Japanese journal of radiology · 2025Review
- Imaging Microstructural Parameters of Breast Tumor in Patient Using Time-Dependent Diffusion: A Feasibility Study.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cytological features such as cell size and intracellular morphology provide fundamental information on cell status and hence may provide specific information on changes that arise within biological tissues. Such information is usually obtained by invasive biopsy in current clinical practice, which suffers several well-known disadvantages. Recently, novel MRI methods such as IMPULSED (imaging microstructural parameters using limited spectrally edited diffusion) have been developed for direct measurements of mean cell size non-invasively. The IMPULSED protocol is based on using temporal diffusion spectroscopy (TDS) to combine measurements of water diffusion over a wide range of diffusion times to probe cellular microstructure over varying length scales. IMPULSED has been shown to provide rapid, robust, and reliable mapping of mean cell size and is suitable for clinical imaging. More recently, cell size distributions have also been derived by appropriate analyses of data acquired with IMPULSED or similar sequences, which thus provides MRI-cytometry. This review summarizes the basic principles, practical implementations, validations, and example applications of MR cell size imaging based on TDS and demonstrates how cytometric information can be used in various applications. In addition, the limitations and potential future directions of MR cytometry are identified including the diagnosis of nonalcoholic steatohepatitis of the liver and the assessment of treatment response of cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.