ArticleCurrent biology : CB2021
Larval Zebrafish Use Olfactory Detection of Sodium and Chloride to Avoid Salt Water.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish.Nature communications · 2026Article
- Gut distension evokes rapid neural dynamics in vagal and hindbrain populations of larval zebrafish.iScience · 2026Article
- PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026Article
- Early life chronic stress-disrupted activity of the dorsal raphe nucleus selectively drives behavioral impairments.Communications biology · 2026Article
- Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain.Nature communications · 2026Article
- Enhanced multisensory integration in the olfactory bulb of the Mexican cavefish.bioRxiv : the preprint server for biology · 2026Article
- Synchronization of behavioral and cardiac dynamics in larval zebrafish.Cell reports · 2026Article
- Attentional switching in larval zebrafish.Science advances · 2025Article
- Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2025Article
- Evaluating the therapeutic potential of BSA-reduced mussel-derived selenium nanoparticles to mitigate copper sulfate-induced hepatic damage and neurodegeneration in a zebrafish model.Frontiers in genetics · 2025Article
- Ectopic taste receptors in animal physiology: evolutionary conservation and functional diversification.Frontiers in cell and developmental biology · 2025Review
- Environmental and molecular control of tissue-specific ionocyte differentiation in zebrafish.Development (Cambridge, England) · 2024Article
- The preoptic area and dorsal habenula jointly support homeostatic navigation in larval zebrafish.Current biology : CB · 2024Article
- Environmental and molecular control of tissue-specific ionocyte differentiation in zebrafish.bioRxiv : the preprint server for biology · 2024Article
- Assessment of the effect of tricaine (MS-222)-induced anesthesia on brain-wide neuronal activity of zebrafish (Frontiers in neuroscience · 2024Article
- An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish.Nature communications · 2023Article
- Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry.Journal of virology · 2022Article
- Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish.Nature communications · 2022Article
- A scalable assay for chemical preference of small freshwater fish.Frontiers in behavioral neuroscience · 2022Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Salinity levels constrain the habitable environment of all aquatic organisms. Zebrafish are freshwater fish that cannot tolerate high-salt environments and would therefore benefit from neural mechanisms that enable the navigation of salt gradients to avoid high salinity. Yet zebrafish lack epithelial sodium channels, the primary conduit land animals use to taste sodium. This suggests fish may possess novel, undescribed mechanisms for salt detection. In the present study, we show that zebrafish indeed respond to small temporal increases in salt by reorienting more frequently. Further, we use calcium imaging techniques to identify the olfactory system as the primary sense used for salt detection, and we find that a specific subset of olfactory receptor neurons encodes absolute salinity concentrations by detecting monovalent anions and cations. In summary, our study establishes that zebrafish larvae have the ability to navigate and thus detect salinity gradients and that this is achieved through previously undescribed sensory mechanisms for salt detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.