ArticleEpilepsia2021
A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia.
Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Clarifications regarding bumetanide for neonatal seizures.Epilepsia · 2022Trial
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered PI3K/mTOR Signaling within the Forebrain Leads to Respiratory Deficits in a Mouse Model of Epilepsy.eNeuro · 2025Article
- Article
- Burst-Suppression EEG Reactivity to Photic Stimulation-A Translational Biomarker in Hypoxic-Ischemic Brain Injury.Biomolecules · 2024Article
- The effects of COHeliyon · 2024Article
- Apnoea suppresses brain activity in infants.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Fetal brain response to worsening acidosis: an experimental study in a fetal sheep model of umbilical cord occlusions.Scientific reports · 2023Article
- Mechanisms underlying pathological cortical bursts during metabolic depletion.Nature communications · 2023Article
- Carbogen-Induced Respiratory Acidosis Blocks Experimental Seizures by a Direct and Specific Inhibition of NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Animal Models of Epilepsy: A Phenotype-oriented Review.Aging and disease · 2022Review
- A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia.Epilepsia · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBirth asphyxia (BA) is often associated with seizures that may exacerbate the ensuing hypoxic-ischemic encephalopathy. In rodent models of BA, exposure to hypoxia is used to evoke seizures, that commence already during the insult. This is in stark contrast to clinical BA, in which seizures are typically seen upon recovery. Here, we introduce a term-equivalent rat model of BA, in which seizures are triggered after exposure to asphyxia.
methodsPostnatal day 11-12 male rat pups were exposed to steady asphyxia (15 min; air containing 5% O
resultsBoth protocols decreased blood pH to <7.0 and brain pH from 7.3 to 6.7 and led to a fall in base excess by 20 mmol·L SIGNIFICANCE: The rate of brain pH recovery has a strong influence on post-asphyxia seizure propensity. The recurring hypoxic episodes during intermittent asphyxia promote neuronal excitability, which leads to seizures only after the suppressing effect of the hypercapnic acidosis is relieved. The present rodent model of BA is to our best knowledge the first one in which, consistent with clinical BA, behavioral and electrographic seizures are triggered after and not during the BA-mimicking insult.
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