Evidence map›Paper›PMID 33338108›Full record

ArticleRevista da Sociedade Brasileira de Medicina Tropical2020

Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment.

Saulo Gomes de Oliveira, Ilana Brito Ferraz de Souza, Taynan da Silva Constantino, Paula Carolina Valença Silva, Elker Lene Santos de Lima, Maria Tereza Cartaxo Muniz, Ana Lúcia Coutinho Domingues

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista da Sociedade Brasileira de Medicina Tropical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Saulo Gomes de OliveiraUniversidade Federal de Pernambuco, Centro Acadêmico de Vitória, Vitória de Santo Antão, PE, Brasil.
Ilana Brito Ferraz de SouzaUniversidade Federal de Pernambuco, Centro Acadêmico de Vitória, Vitória de Santo Antão, PE, Brasil.
Taynan da Silva ConstantinoUniversidade Federal de Pernambuco, Centro Acadêmico de Vitória, Vitória de Santo Antão, PE, Brasil.
Paula Carolina Valença SilvaUniversidade Federal de Pernambuco, Centro Acadêmico de Vitória, Vitória de Santo Antão, PE, Brasil.
Elker Lene Santos de LimaUniversidade de Pernambuco, Centro de Oncohematologia Pediátrica, Recife, PE, Brasil.
Maria Tereza Cartaxo MunizUniversidade de Pernambuco, Centro de Oncohematologia Pediátrica, Recife, PE, Brasil.
Ana Lúcia Coutinho DominguesUniversidade Federal de Pernambuco, Departamento de Medicina Clínica, Recife, PE, Brasil.ORCID http://orcid.org/0000-0002-1824-7090
Universidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.

methodsThis was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.

resultsA risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.

conclusionsThis study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

Indexed as

Mannose-Binding LectinSchistosomiasisAnimalsBrazilExonsGenetic Predisposition to DiseaseGenotypeHumansLiver CirrhosisPolymorphism, GeneticPolymorphism, Single NucleotideRetrospective StudiesMannose-Binding Lectin

Identifiers

PMID33338108
PMCPMC7747812
OpenAlexW3112430439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.