Evidence map›Paper›PMID 33337984›Full record

ArticleSports health2021

Functional Resistance Training to Improve Knee Strength and Function After Acute Anterior Cruciate Ligament Reconstruction: A Case Study.

Scott R Brown, Edward P Washabaugh, Aviroop Dutt-Mazumder, Edward M Wojtys, Riann M Palmieri-Smith, Chandramouli Krishnan

Registry-linked trialOpen access · bronzeAbstract readCase Reports
In one paragraph

Article in Sports health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07642752 (Effects of Perturbation Training Versus Task-oriented Functional Activities on Pain, Range of Motion, Balance and Function in Post-anterior Cruciate Ligament Reconstruction), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07642752 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Perturbation Training Versus Task-oriented Functional Activities on Pain, Range of Motion, Balance and Function in Post-anterior Cruciate Ligament Reconstruction

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled54ConditionsAnterior Cruciate Ligament InjuriesArmsPerturbation Training Group, Task-Oriented Functional Activities Group, Control Group (Standard Rehabilitation Protocol)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Scott R BrownNeuromuscular and Rehabilitation Robotics Laboratory (NeuRRo Lab), Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Edward P WashabaughNeuromuscular and Rehabilitation Robotics Laboratory (NeuRRo Lab), Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Aviroop Dutt-MazumderNeuromuscular and Rehabilitation Robotics Laboratory (NeuRRo Lab), Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Edward M WojtysDepartment of Orthopaedic Surgery, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Riann M Palmieri-SmithNeuromuscular and Rehabilitation Robotics Laboratory (NeuRRo Lab), Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Chandramouli KrishnanNeuromuscular and Rehabilitation Robotics Laboratory (NeuRRo Lab), Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Michigan Medicine · USUniversity of Michigan–Ann Arbor · US

Funding

Functional Resistance Training during Gait: A Novel Intervention to Improve Knee Function after ACL ReconstructionR21HD092614 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KRISHNAN, CHANDRAMOULI, PALMIERI-SMITH, RIANN MARIE · 2017 to 2018
$428k
NICHD NIH HHS R21 HD092614
6 · The paper itself

Abstract

backgroundThigh muscle weakness after anterior cruciate ligament reconstruction (ACLR) can persist after returning to activity. While resistance training can improve muscle function, "nonfunctional" training methods are not optimal for inducing transfer of benefits to activities such as walking. Here, we tested the feasibility of a novel functional resistance training (FRT) approach to restore strength and function in an individual with ACLR. HYPOTHESIS: FRT would improve knee strength and function after ACLR. STUDY

designCase report. LEVEL OF EVIDENCE: Level 5.

methodsA 15-year-old male patient volunteered for an 8-week intervention where he performed 30 minutes of treadmill walking, 3 times per week, while wearing a custom-designed knee brace that provided resistance to the thigh muscles of his ACLR leg. Thigh strength, gait mechanics, and corticospinal and spinal excitability were assessed before and immediately after the 8-week intervention. Voluntary muscle activation was evaluated immediately after the intervention.

resultsKnee extensor and flexor strength increased in the ACLR leg from pre- to posttraining (130 to 225 N·m [+74%] and 44 to 88 N·m [+99%], respectively) and increases in between-limb extensor and flexor strength symmetry (45% to 92% [+74%] and 47% to 72% [+65%], respectively) were also noted. After the intervention, voluntary muscle activation in the ACLR leg was 72%, compared with the non-ACLR leg at 75%. Knee angle and moment during late stance phase decreased (ie, improved) in the ACLR leg and appeared more similar to the non-ACLR leg after FRT training (18° to 14° [-23.4] and 0.07 to -0.02 N·m·kg

conclusionA full 8 weeks of FRT that targeted both quadriceps and hamstring muscles lead to improvements in strength and gait, suggesting that FRT may constitute a promising and practical alternative to traditional methods of resistance training. CLINICAL RELEVANCE: FRT may serve as a viable approach to improve knee strength and function after ACL reconstruction.

Indexed as

Muscle StrengthAdolescentAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionBasketballBiomechanical PhenomenaBracesEquipment DesignExercise TherapyGaitHamstring MusclesHumansKneeLateral Ligament, AnkleMalePyramidal TractsACLbiomechanicseddy current brakeH-reflexisometrickinematicskineticsrehabilitationroboticsTMS

Identifiers

PMID33337984
PMCPMC8167352
OpenAlexW3112156290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.