Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors at 1 institution in 1 country.
Dorothy E VatnerDepartment of Cell Biology and Molecular Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey.ORCID 0000-0002-2628-6217
Jie ZhangDepartment of Cell Biology and Molecular Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey.
Xin ZhaoDepartment of Cell Biology and Molecular Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey.
Lin YanDepartment of Cell Biology and Molecular Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey.
Raymond KudejDepartment of Cell Biology and Molecular Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey.
Stephen F VatnerDepartment of Cell Biology and Molecular Medicine, Rutgers University, New Jersey Medical School, Newark, New Jersey.ORCID 0000-0003-0521-8634
Rutgers, The State University of New Jersey · US
Funding
Skeletal Muscle Basis for Improved Exercise Endurance in RGS14 KOR01HL106511 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2011 to 2019
$3.8M
RGS 14 Disruption, Vascular Effects Leading to CardioprotectionR01HL124282 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2015 to 2018
$2.4M
Angiogenesis Protection Induced by sFRP3 Myocyte/Vascular Cross-TalkR01HL137405 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, DOROTHY EILEEN, VATNER, STEPHEN F · 2017 to 2020
$2.2M
Skeletal Muscle and Brown Adipose Mechanisms Mediating Cardiovascular Risk Factor Protection in RGS14 KOR01HL137368 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2017 to 2020
$2.1M
Vascular Protection in Hibernating WoodchucksR01HL130848 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2016 to 2019
$1.8M
Vevo 3100 High Resolution Imaging SystemS10OD025238 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI VATNER, STEPHEN F · 2018 to 2018
$459k
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01HL106511HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01HL130848HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01HL137368HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) R01HL137405NHLBI NIH HHS R01 HL106511NHLBI NIH HHS R01 HL124282NHLBI NIH HHS R01 HL130848NHLBI NIH HHS R01 HL137368NHLBI NIH HHS R01 HL137405NIH HHS S10 OD025238
6 · The paper itself
Abstract
Most studies on ischemic preconditioning (IPC) use one or two ischemic stimuli before examining cardioprotection. To better simulate the clinical situation, we examined, in pigs, the effects of six episodes of 10 min coronary artery occlusion (CAO) 12 h apart, followed by 60 min CAO. We named this model the fourth window of IPC. To determine the novel mechanisms mediating cardioprotection in the fourth window, gene analysis was examined in fourth window IPC cardiac tissue 60 min after the last episode of 10 min CAO. Secreted frizzled-related protein 3 (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Secreted frizzled protein 3 is a novel cardioprotective mechanism unique to the clinically relevant fourth window of ischemic preconditioning. · full record | OpenQuestion