Evidence map›Paper›PMID 33337577›Full record

ReviewActa physiologica (Oxford, England)2021

Uterine contractions in rodent models and humans.

Manasi Malik, Michelle Roh, Sarah K England

Open access · hybridAbstract readReview
In one paragraph

Review in Acta physiologica (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. An update on pacemaking in the myometrium.The Journal of physiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cellulose Plant-Derived Scaffolds as a Tool for Myometrium Modeling.International journal of molecular sciences · 2025
    Article
  8. Article
  9. Electrical wave generation and spatial organization in uterine tissue.Journal of the Royal Society, Interface · 2025
    Article
  10. Article
  11. Article
  12. A bioprinted model of pregnant human uterine myometrium.Frontiers in bioengineering and biotechnology · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Mapping uterine calcium dynamics during the ovulatory cycle in live mice.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Manasi MalikCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-4203-962X
Michelle RohCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Sarah K EnglandCenter for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-4247-0281
Washington University in St. Louis · US

Funding

REGULATION OF UTERINE SMOOTH MUSCLE EXCITABILITYR01HD037831 · NICHD · WASHINGTON UNIVERSITY · PI ENGLAND, SARAH K. · 1999 to 2023
$7.0M
A NOVEL MOLECULAR MECHANISM FOR STIMULATING UTERINE CONTRACTILITY BY OXYTOCINR01HD088097 · NICHD · WASHINGTON UNIVERSITY · PI Sarah K. England, Celia M Santi · 2016 to 2026
$4.1M
Quantitative and computational characterization of oxytocin receptor signaling: Administrative supplementR01HD096737 · NICHD · WASHINGTON UNIVERSITY · PI ENGLAND, SARAH K., IMOUKHUEDE, PRINCESS IZEVBUA · 2019 to 2023
$2.8M
The effects of oxytocin receptor genetic variants on oxytocin responseF30HD097925 · NICHD · WASHINGTON UNIVERSITY · PI MALIK, MANASI · 2019 to 2021
$113k
NICHD NIH HHS F30 HD097925NICHD NIH HHS R01 HD037831NICHD NIH HHS R01 HD088097NICHD NIH HHS R01 HD096737
6 · The paper itself

Abstract

Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.

Indexed as

Premature BirthUterine ContractionAnimalsFemaleGuinea PigsHumansInfant, NewbornMiceMyometriumPregnancyRatsRodentiaUterusanimal modelscontractionmyometriumparturitionpregnancyspecies differencesuterus

Identifiers

PMID33337577
PMCPMC8047897
OpenAlexW3118032714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.