Evidence map›Paper›PMID 33337436›Full record

ArticleOncology nursing forum2021

Change in Health-Related Quality of Life Among Individuals With Cancer Undergoing Smoking Cessation Treatment Involving Varenicline.

Julia R May, Nancy C Jao, Kristen McCarter, Elizabeth Klass, Timothy Pearman, Frank Leone, Robert A Schnoll, Brian Hitsman

Abstract read
In one paragraph

Article in Oncology nursing forum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Nicotine receptor partial agonists for smoking cessation.The Cochrane database of systematic reviews · 2023
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia R MayNorthwestern University.
Nancy C JaoNorthwestern University.
Kristen McCarterUniversity of Newcastle.
Elizabeth Klass
Timothy PearmanNorthwestern University.
Frank LeoneUniversity of Pennsylvania Presbyterian Medical Center.
Robert A SchnollUniversity of Pennsylvania.
Brian HitsmanNorthwestern University.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Extended Duration Varenicline for Smoking Among Cancer Patients: A Clinical TrialR01CA165001 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHNOLL, ROBERT ADAM · 2012 to 2016
$3.0M
A Patient-Oriented Research Mentoring Program in Tobacco Dependence ResearchK24DA045244 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Robert Adam Schnoll · 2018 to 2026
$1.7M
NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA165001NIDA NIH HHS K24 DA045244
6 · The paper itself

Abstract

objectivesTo determine whether health-related quality of life (HRQOL) among individuals with cancer is undermined by smoking cessation treatment involving varenicline. SAMPLE &

settingParticipants (N = 103) were daily smokers with cancer (up to five years postdiagnosis) who completed a placebo-controlled trial of standard versus extended duration varenicline. METHODS & VARIABLES: For this secondary study, participants were selected based on having completed the SF-12® at weeks 0, 1, 12, and 24. Using separate repeated measures multivariate analysis of variance, change in SF-12 scores was evaluated by time and by cancer treatment, varenicline duration, and quit status at week 24.

resultsThere was no change in any of the three HRQOL scores by time or by cancer treatment status, varenicline duration, or quit status. Average emotional HRQOL score across time was significantly higher for quitters versus smokers. IMPLICATIONS FOR NURSING: Varenicline, including long-term treatment, does not appear to adversely affect HRQOL, which is highly relevant to oncology nurses who are well positioned to assist with the pharmacologic treatment of tobacco dependence.

Indexed as

NeoplasmsSmoking CessationBenzazepinesHumansNicotinic AgonistsQuality of LifeTreatment OutcomeVareniclineBenzazepinesNicotinic AgonistsVareniclinecancernursingoncologyquality of lifesmoking cessationvarenicline

Identifiers

PMID33337436
PMCPMC7983103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.