Evidence map›Paper›PMID 33337320›Full record

ArticleeLife2020

Neuropeptide VF neurons promote sleep via the serotonergic raphe.

Daniel A Lee, Grigorios Oikonomou, Tasha Cammidge, Andrey Andreev, Young Hong, Hannah Hurley, David A Prober

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

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  12. Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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  19. Review
  20. Migraine and Sleep-An Unexplained Association?International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel A LeeCalifornia Institute of Technology, Division of Biology and Biological Engineering, Pasadena, United States.ORCID 0000-0001-7411-2740
Grigorios OikonomouCalifornia Institute of Technology, Division of Biology and Biological Engineering, Pasadena, United States.ORCID 0000-0001-6797-7375
Tasha CammidgeCalifornia Institute of Technology, Division of Biology and Biological Engineering, Pasadena, United States.
Andrey AndreevCalifornia Institute of Technology, Division of Biology and Biological Engineering, Pasadena, United States.ORCID 0000-0002-7833-1390
Young HongCalifornia Institute of Technology, Division of Biology and Biological Engineering, Pasadena, United States.ORCID 0000-0001-9548-5511
Hannah HurleyCalifornia Institute of Technology, Division of Biology and Biological Engineering, Pasadena, United States.
David A ProberCalifornia Institute of Technology, Division of Biology and Biological Engineering, Pasadena, United States.ORCID 0000-0002-7371-4675
California Institute of Technology · US

Funding

Neuropeptidergic Regulation of Zebrafish SleepR01NS070911 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PROBER, DAVID AARON · 2011 to 2020
$3.5M
Regulation of Zebrafish Sleep by Neuromedin UR01NS101158 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PROBER, DAVID AARON · 2017 to 2020
$1.4M
Mechanisms of Sleep Regulation by EGFR-Mediated Neural and Molecular CircuitsK99NS097683 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI LEE, DANIEL ALLEN · 2016 to 2017
$182k
Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and BehaviorF32NS082010 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI OIKONOMOU, GRIGORIOS · 2012 to 2015
$159k
Regulation of Sleep and Circadian Behaviors by TGF-alpha SignalingF32NS084769 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI LEE, DANIEL ALLEN · 2013 to 2015
$159k
Brain and Behavior Research Foundation 25392NINDS NIH HHS F32 NS082010NINDS NIH HHS F32 NS084769NINDS NIH HHS K99 NS097683NINDS NIH HHS R01 NS070911NINDS NIH HHS R01 NS101158
6 · The paper itself

Abstract

Although several sleep-regulating neuronal populations have been identified, little is known about how they interact with each other to control sleep/wake states. We previously identified neuropeptide VF (NPVF) and the hypothalamic neurons that produce it as a sleep-promoting system (Lee et al., 2017). Here we show using zebrafish that

Indexed as

AnimalsHypothalamusNeural PathwaysNeuronsNeuropeptidesRaphe NucleiSleepZebrafishNeuropeptidesneuropeptide VFgeneticsneural circuitneuropeptide VFneurosciencerapheserotoninsleepzebrafish

Identifiers

PMID33337320
PMCPMC7748413
OpenAlexW2996924909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.