Evidence map›Paper›PMID 33337028›Full record

ArticleBrain and behavior2021

Parcellation-based anatomic modeling of the default mode network.

Zainab Sandhu, Onur Tanglay, Isabella M Young, Robert G Briggs, Michael Y Bai, Micah L Larsen, Andrew K Conner, Vukshitha Dhanaraj, Yueh-Hsin Lin, Jorge Hormovas and 3 more

Abstract read
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  12. Parcellation-Based Connectivity Model of the Judgement Core.Journal of personalized medicine · 2023
    Article
  13. Functional connectivity reveals different brain networks underlying the idiopathic foreign accent syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zainab SandhuDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Onur TanglayCentre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia.ORCID 0000-0002-2071-6909
Isabella M YoungCingulum Health, Sydney, NSW, Australia.ORCID 0000-0001-7639-6679
Robert G BriggsDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Michael Y BaiCentre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia.ORCID 0000-0002-5764-7740
Micah L LarsenDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Andrew K ConnerDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Vukshitha DhanarajCentre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia.
Yueh-Hsin LinCentre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia.
Jorge HormovasCentre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia.
Rannulu Dineth FonsekaCentre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia.
Chad A GlennDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Michael E SughrueCentre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, NSW, Australia.ORCID 0000-0001-5407-2585

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

backgroundThe default mode network (DMN) is an important mediator of passive states of mind. Multiple cortical areas, such as the anterior cingulate cortex, posterior cingulate cortex, and lateral parietal lobe, have been linked in this processing, though knowledge of network connectivity had limited tractographic specificity.

methodsUsing resting-state fMRI studies related to the DMN, we generated an activation likelihood estimation (ALE). We built a tractographical model of this network based on the cortical parcellation scheme previously published under the Human Connectome Project. DSI-based fiber tractography was performed to determine the structural connections between cortical parcellations comprising the network.

resultsSeventeen cortical regions were found to be part of the DMN: 10r, 31a, 31pd, 31pv, a24, d23ab, IP1, p32, POS1, POS2, RSC, PFm, PGi, PGs, s32, TPOJ3, and v23ab. These regions showed consistent interconnections between adjacent parcellations, and the cingulum was found to connect the anterior and posterior cingulate clusters within the network.

conclusionsWe present a preliminary anatomic model of the default mode network. Further studies may refine this model with the ultimate goal of clinical application.

Indexed as

ConnectomeDefault Mode NetworkHumansMagnetic Resonance ImagingNerve NetNeural PathwaysParietal LobeALEanatomydefault mode networkparcellationtractographywhite matter

Identifiers

PMID33337028
PMCPMC7882165

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.