ReviewIntensive care medicine experimental2020
Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies.
Review in Intensive care medicine experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Sedation in Acute Ischemic Stroke: Pathophysiological Basis and Evidence for Commonly Used Agents.Translational stroke research · 2026Review
- PKM2 from hyperactive neuron aggravate lung injury post-stroke by promoting FOXO3A/TXNIP mitochondria translocation in mice.Redox biology · 2026Article
- Case Report: Neurogenic pulmonary edema coupled with myocardial damage following tenecteplase thrombolysis for acute ischemic stroke.Frontiers in cardiovascular medicine · 2026Article
- Predicting Stroke Incidence Using Estimated Glucose Disposal Rate Index in the Population with Cardiovascular-Kidney-Metabolic Syndrome Stage 0-3 in the Chinese Middle-Aged and Elderly Population.Cardiorenal medicine · 2026Observational
- Baicalin-geniposide attenuates pulmonary inflammation and vascular injury via HMGB1 blockade: insights from a cerebral ischemia-reperfusion model and implications for pulmonary hypertension.Frontiers in pharmacology · 2026Article
- The impact of post-stroke pneumonia on survival and functional outcomes: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Catecholamine-Induced Inflammasome Activation in the Heart Following Photothrombotic Stroke.Translational stroke research · 2025Article
- Unravelling the role of electrocardiogram changes and ejection fraction in ischaemic stroke outcomes.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Review
- A clinical study on ozone autohemotherapy for the treatment of acute ischemic stroke.Frontiers in medicine · 2025Article
- Post-stroke mortality in ICU patients with serum glucose-potassium ratio: an analysis of MIMIC-IV database.Frontiers in neurology · 2025Article
- Stroke and Distal Organ Damage: Exploring Brain-Kidney Crosstalk.Neurochemical research · 2024Review
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- Pulmonary consequences of experimentally induced stroke: differences between global and focal cerebral ischemia.Frontiers in physiology · 2024Article
- The aging ovary impairs acute stroke outcomes.Journal of neuroinflammation · 2023Article
- Risk Factors Associated With Neurological and Extra-Neurological Complications and Mortality in Patients With Stroke.Cureus · 2023Article
- Inflammasome-Regulated Pyroptotic Cell Death in Disruption of the Gut-Brain Axis After Stroke.Translational stroke research · 2022Article
- Prolonged increased neutrophil-to-lymphocyte ratio is associated with mortality after successful revascularization for treatment of acute ischemic stroke.BMC neurology · 2022Article
- Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets.International journal of molecular sciences · 2022Review
- Selective Brain Cooling: A New Horizon of Neuroprotection.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute ischaemic stroke is associated with a high risk of non-neurological complications, which include respiratory failure, cardiovascular dysfunction, kidney and liver injury, and altered immune and endocrine function. The aim of this manuscript is to provide an overview of the main forms of stroke-induced distal organ damage, providing new pathophysiological insights and recommendations for clinical management.Non-neurological complications of stroke can affect outcomes, with potential for serious short-term and long-term consequences. Many of these complications can be prevented; when prevention is not feasible, early detection and proper management can still be effective in mitigating their adverse impact. The general care of stroke survivors entails not only treatment in the acute setting but also prevention of secondary complications that might hinder functional recovery. Acute ischaemic stroke triggers a cascade of events-including local and systemic activation of the immune system-which results in a number of systemic consequences and, ultimately, may cause organ failure. Understanding the pathophysiology and clinical relevance of non-neurological complications is a crucial component in the proper treatment of patients with acute stroke.Little evidence-based data is available to guide management of these complications. There is a clear need for improved surveillance and specific interventions for the prevention, early diagnosis, and proper management of non-neurological complications during the acute phase of ischaemic stroke, which should reduce morbidity and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.