Evidence map›Paper›PMID 33336263›Full record

ArticleIntensive care medicine experimental2020

Continuous external negative pressure improves oxygenation and respiratory mechanics in Experimental Lung Injury in Pigs - A pilot proof-of-concept trial.

Martin Scharffenberg, Jakob Wittenstein, Moritz Herzog, Sebastian Tauer, Luigi Vivona, Raphael Theilen, Thomas Bluth, Thomas Kiss, Thea Koch, Giuseppe Fiorentino and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06049173 (Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis in the Patients With Cardiac Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06049173 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis in the Patients With Cardiac Surgery

TypeinterventionalSponsorJilai XiaoRan2023 to 2024Enrolled77ConditionsPostoperative Pulmonary Atelectasis, Negative Pressure TherapyArmsNegative extra-abdominal pressure (NEXAP)-based lung recruitment maneuver, stepwise positive end-expiratory pressure (PEEP)-based lung recruitment maneuver
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Influence of the chest wall on respiratory function at birth in near-term lambs.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Martin ScharffenbergPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Jakob WittensteinPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Moritz HerzogPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Sebastian TauerPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Luigi VivonaDepartment of Pathophysiology and Transplantation, University of Milan, Via Francesco Sforza 35, 20122, Milano, Italia.
Raphael TheilenPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Thomas BluthPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Thomas KissPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Thea KochPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Giuseppe FiorentinoDevision of Respiratory Physiopathology, Monaldi Hospital, Naples, Italy.
Marcelo Gama de AbreuPulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Robert HuhlePulmonary Engineering Group, Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus at Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. robert.huhle@tu-dresden.de.ORCID http://orcid.org/0000-0003-2185-1819
University Hospital Carl Gustav Carus · DEOspedale Monaldi · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContinuous external negative pressure (CENP) during positive pressure ventilation can recruit dependent lung regions. We hypothesised that CENP applied regionally to the thorax or the abdomen only, increases the caudal end-expiratory transpulmonary pressure depending on positive end-expiratory pressure (PEEP) in lung-injured pigs. Eight pigs were anesthetised and mechanically ventilated in the supine position. Pressure sensors were placed in the left pleural space, and a lung injury was induced by saline lung lavages. A CENP shell was placed at the abdomen and thorax (randomised order), and animals were ventilated with PEEP 15, 7 and zero cmH

resultsCompared to positive pressure ventilation alone, the caudal transpulmonary pressure was significantly increased by CENP of ≤ 20 cmH

conclusionsIn this lung injury model in pigs, CENP increased the end-expiratory caudal transpulmonary pressure. This lead to a shift of lung aeration towards dependent zones as well as improved respiratory mechanics and oxygenation, especially when CENP was applied to the abdomen as compared to the thorax. CENP values ≤ 20 cmH

Indexed as

Acute respiratory distress syndromeARDSCENPContinuous external negative pressureElectrical impedance tomographyLung mechanicsMechanical ventilationNegative pressure ventilationPleural pressureTranspulmonary pressure

Identifiers

PMID33336263
PMCPMC7746426
OpenAlexW3115787319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.