Evidence map›Paper›PMID 33336201›Full record

ReviewPatterns (New York, N.Y.)2020

A New Era for Space Life Science: International Standards for Space Omics Processing.

Lindsay Rutter, Richard Barker, Daniela Bezdan, Henry Cope, Sylvain V Costes, Lovorka Degoricija, Kathleen M Fisch, Mariano I Gabitto, Samrawit Gebre, Stefania Giacomello and 9 more

Abstract readReview
In one paragraph

Review in Patterns (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lindsay RutterTransborder Medical Research Center and Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Richard BarkerDepartment of Botany, University of Wisconsin, Madison, WI 53706, USA.
Daniela BezdanInstitute of Medical Virology and Epidemiology of Viral Diseases, University Hospital, Tubingen, Germany.
Henry CopeSchool of Computer Science, University of Nottingham, Nottingham NG8 1BB, UK.
Sylvain V CostesSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Lovorka DegoricijaKBR, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Kathleen M FischCenter for Computational Biology & Bioinformatics, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Mariano I GabittoFlatiron Institute, Center for Computational Biology, Simons Foundation, New York, NY 10010, USA.
Samrawit GebreKBR, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Stefania GiacomelloSciLifeLab, KTH Royal Institute of Technology, Stockholm 17165, Sweden.
Simon GilroyDepartment of Botany, University of Wisconsin, Madison, WI 53706, USA.
Stefan J GreenGenome Research Core, University of Illinois at Chicago, Chicago, IL 60612, USA.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.
Sigrid S ReinschSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Nathaniel J SzewczykOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University, Athens, OH 45701, USA.
Deanne M TaylorDepartment of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jonathan M GalazkaSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Raul HerranzCentro de Investigaciones Biológicas "Margarita Salas" (CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain.
Masafumi MurataniTransborder Medical Research Center and Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
The Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3M
NCATS NIH HHS UL1 TR001442NIMH NIH HHS R01 MH117406
6 · The paper itself

Abstract

Space agencies have announced plans for human missions to the Moon to prepare for Mars. However, the space environment presents stressors that include radiation, microgravity, and isolation. Understanding how these factors affect biology is crucial for safe and effective crewed space exploration. There is a need to develop countermeasures, to adapt plants and microbes for nutrient sources and bioregenerative life support, and to limit pathogen infection. Scientists across the world are conducting space omics experiments on model organisms and, more recently, on humans. Optimal extraction of actionable scientific discoveries from these precious datasets will only occur at the collective level with improved standardization. To address this shortcoming, we established ISSOP (International Standards for Space Omics Processing), an international consortium of scientists who aim to enhance standard guidelines between space biologists at a global level. Here we introduce our consortium and share past lessons learned and future challenges related to spaceflight omics.

Indexed as

ESAGeneLabISSOPJAXAmetadataNASAomicsspace biologystandardizationTwins study

Identifiers

PMID33336201
PMCPMC7733874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.