Evidence map›Paper›PMID 33336196›Full record

ArticlePatterns (New York, N.Y.)2020

A Blueprint for Identifying Phenotypes and Drug Targets in Complex Disorders with Empirical Dynamics.

Madison S Krieger, Joshua M Moreau, Haiyu Zhang, May Chien, James L Zehnder, Morgan Craig

Open access · goldAbstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The highs and lows of cyclic thrombocytopenia.British journal of haematology · 2024
    Review
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Madison S KriegerDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Joshua M MoreauDepartment of Dermatology, University of California, San Francisco, CA, USA.
Haiyu ZhangDepartment of Pathology, Stanford School of Medicine, Stanford, CA, USA.
May ChienDepartment of Medicine (Hematology), Stanford, CA, USA.
James L ZehnderDepartment of Pathology, Stanford School of Medicine, Stanford, CA, USA.
Morgan CraigDépartement de Mathématiques et de Statistique, Université de Montréal, Montréal, QC, Canada.
Stanford Medicine · USCentre Hospitalier Universitaire Sainte-Justine · CAHarvard University · USUniversity of California, San Francisco · US

Funding

Quantification and prediction of treatment efficacy for HIV cure strategiesDP5OD019851 · OD · JOHNS HOPKINS UNIVERSITY · PI HILL, ALISON LYNN · 2014 to 2018
$2.1M
NIH HHS DP5 OD019851
6 · The paper itself

Abstract

A central challenge in medicine is translating from observational understanding to mechanistic understanding, where some observations are recognized as causes for the others. This can lead not only to new treatments and understanding, but also to recognition of novel phenotypes. Here, we apply a collection of mathematical techniques (

Indexed as

blood disorderscausal inferencecomplex disordersimmunology

Identifiers

PMID33336196
PMCPMC7733879
OpenAlexW3096856821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.