Evidence map›Paper›PMID 33336195›Full record

ArticlePatterns (New York, N.Y.)2020

Parallel Factor Analysis Enables Quantification and Identification of Highly Convolved Data-Independent-Acquired Protein Spectra.

Filip Buric, Jan Zrimec, Aleksej Zelezniak

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Filip BuricDepartment of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, Gothenburg 412 96, Sweden.
Jan ZrimecDepartment of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, Gothenburg 412 96, Sweden.
Aleksej ZelezniakDepartment of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, Gothenburg 412 96, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-throughput data-independent acquisition (DIA) is the method of choice for quantitative proteomics, combining the best practices of targeted and shotgun approaches. The resultant DIA spectra are, however, highly convolved and with no direct precursor-fragment correspondence, complicating biological sample analysis. Here, we present CANDIA (canonical decomposition of data-independent-acquired spectra), a GPU-powered unsupervised multiway factor analysis framework that deconvolves multispectral scans to individual analyte spectra, chromatographic profiles, and sample abundances, using parallel factor analysis. The deconvolved spectra can be annotated with traditional database search engines or used as high-quality input for

Indexed as

big datacanonical decompositiondata-independent acquisitiondeconvolutionmass spectrometryPARAFACproteomicstensor factorization

Identifiers

PMID33336195
PMCPMC7733873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.