Evidence map›Paper›PMID 33336185›Full record

ArticleVaccine: X2020

VANGUARD®crLyme: A next generation Lyme disease vaccine that prevents

Richard T Marconi, David Garcia-Tapia, Jacquelien Hoevers, Nicole Honsberger, Vickie L King, Dianne Ritter, Denise J Schwahn, Leroy Swearingin, Angela Weber, M Teresa C Winkler and 1 more

Open access · goldAbstract read
In one paragraph

Article in Vaccine: X, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Protective efficacy of mutant strains ofInfection and immunity · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Borrelia surface proteins: new horizons in Lyme disease diagnosis.Applied microbiology and biotechnology · 2025
    Review
  8. A Lyme disease mRNA vaccine targetingMolecular therapy. Nucleic acids · 2025
    Article
  9. Article
  10. Article
  11. A single immunization ofInfection and immunity · 2024
    Article
  12. Article
  13. Infection and immunity · 2024
    Article
  14. Article
  15. Current and emerging approaches for eliminatingFrontiers in microbiology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Richard T MarconiDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, United States.
David Garcia-TapiaZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Jacquelien HoeversZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Nicole HonsbergerZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Vickie L KingZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Dianne RitterZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Denise J SchwahnZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Leroy SwearinginZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Angela WeberZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
M Teresa C WinklerZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Jason MillershipZoetis Inc., 333 Portage Road, Kalamazoo, MI 49007-4931, United States.
Zoetis (United States) · USVirginia Commonwealth University Medical Center · US

Funding

Chimeric epitope based vaccines for tick borne infectionsR01AI141801 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2019 to 2022
$2.5M
OspC and its role in defining host range and dissemination propertiesR01AI165876 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2022 to 2025
$2.2M
Development of a polyvalent chimeric vaccine for Lyme diseaseR01AI067746 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2006 to 2010
$1.7M
Development of a multi-pathogen chimeritope vaccine for tick borne diseasesR56AI127801 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2017 to 2017
$510k
NIAID NIH HHS R01 AI067746NIAID NIH HHS R01 AI141801NIAID NIH HHS R01 AI165876NIAID NIH HHS R56 AI127801
6 · The paper itself

Abstract

Lyme disease, a public health threat of significance to both veterinary and human medicine, is caused by the tick (

Indexed as

BorreliaBorreliellachimeritopecrLymeLyme diseaseOspAOspCvaccine

Identifiers

PMID33336185
PMCPMC7733144
OpenAlexW3092400315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.