Evidence map›Paper›PMID 33336170›Full record

ReviewChronic diseases and translational medicine2020

Environmental heavy metals and cardiovascular diseases: Status and future direction.

Ai-Min Yang, Kenneth Lo, Tong-Zhang Zheng, Jing-Li Yang, Ya-Na Bai, Ying-Qing Feng, Ning Cheng, Si-Min Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chronic diseases and translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
7.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 154 citations in OpenAlex.

  1. Review
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  13. Effects of PMScientific reports · 2025
    Article
  14. Review
  15. Review
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  20. Associations of a metal mixture and vitamin D with sleep duration among adolescents and young adults from the 2011-2018 NHANES cycles.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025
    Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ai-Min YangHong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China.
Kenneth LoCentre for Global Cardiometabolic Health, Department of Epidemiology, Surgery, and Medicine, Brown University, Providence, RI 02903, USA.
Tong-Zhang ZhengDepartment of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA.
Jing-Li YangDepartment of Epidemiology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, China.
Ya-Na BaiDepartment of Epidemiology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, China.
Ying-Qing FengDepartment of Cardiology and Endocrinology, Guangdong Provincial People's Hospital, Guandong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.
Ning ChengDepartment of Epidemiology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, China.
Si-Min LiuHong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lanzhou University · CNBrown University · USChinese University of Hong Kong · CNGuangdong Academy of Medical Sciences · CN

Funding

Environmental heavy metals and risk of ischemic heart disease and stroke in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)R01ES031391 · NIEHS · BROWN UNIVERSITY · PI LIU, SIMIN, LOTUFO, PAULO ANDRADE · 2020 to 2023
$695k
NIEHS NIH HHS R01 ES031391
6 · The paper itself

Abstract

Cardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly in populations from low- and middle-income countries, where concomitant rapid development occurs. In this review, we 1) assessed the totality, quantity, and consistency of the available epidemiological studies, linking heavy metal exposures to the risk of CVD (including stroke and coronary heart disease); 2) discussed the potential biological mechanisms underlying some tantalizing observations in humans; and 3) identified gaps in our knowledge base that must be investigated in future work. An accumulating body of evidence from both experimental and observational studies implicates exposure to heavy metals, in a dose-response manner, in the increased risk of CVD. The limitations of most existing studies include insufficient statistical power, lack of comprehensive assessment of exposure, and cross-sectional design. Given the widespread exposure to heavy metals, an urgent need has emerged to investigate these putative associations of environmental exposures, either independently or jointly, with incident CVD outcomes prospectively in well-characterized cohorts of diverse populations, and to determine potential strategies to prevent and control the impacts of heavy metal exposure on the cardiometabolic health outcomes of individuals and populations.

Indexed as

Cardiovascular diseaseCoronary heart diseaseHeavy metalHypertensionStroke

Identifiers

PMID33336170
PMCPMC7729107
OpenAlexW3014294573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.