Evidence map›Paper›PMID 33336126›Full record

ArticleEpilepsia open2020

Availability, affordability, and quality of essential antiepileptic drugs in Lao PDR.

Noudy Sengxeu, Hanh Dufat, Farid Boumediene, Somchit Vorachit, Phetvongsinh Chivorakoun, Vimalay Souvong, Chanthanom Manithip, Pierre-Marie Preux, Voa Ratsimbazafy, Jeremy Jost

Open access · goldAbstract read
In one paragraph

Article in Epilepsia open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Noudy SengxeuINSERM Univ. Limoges, CHU Limoges IRD U1094 Tropical Neuroepidemiology Institute of Epidemiology and Tropical Neurology GEIST Limoges France.ORCID https://orcid.org/0000-0002-5715-2051
Hanh DufatNatural Products, Analysis and Synthesis CiTCoM-UMR 8038 CNRS/Université de Paris, Faculty of Health-Pharmacy, Université de Paris Paris France.
Farid BoumedieneINSERM Univ. Limoges, CHU Limoges IRD U1094 Tropical Neuroepidemiology Institute of Epidemiology and Tropical Neurology GEIST Limoges France.
Somchit VorachitLao Association for Patient with epilepsy Vientiane Lao PDR.
Phetvongsinh ChivorakounLao Association for Patient with epilepsy Vientiane Lao PDR.
Vimalay SouvongLao Association for Patient with epilepsy Vientiane Lao PDR.
Chanthanom ManithipFaculty of pharmacy University of Health sciences Vientiane Lao PDR.
Pierre-Marie PreuxINSERM Univ. Limoges, CHU Limoges IRD U1094 Tropical Neuroepidemiology Institute of Epidemiology and Tropical Neurology GEIST Limoges France.
Voa RatsimbazafyINSERM Univ. Limoges, CHU Limoges IRD U1094 Tropical Neuroepidemiology Institute of Epidemiology and Tropical Neurology GEIST Limoges France.
Jeremy JostINSERM Univ. Limoges, CHU Limoges IRD U1094 Tropical Neuroepidemiology Institute of Epidemiology and Tropical Neurology GEIST Limoges France.ORCID https://orcid.org/0000-0001-5543-3741
Inserm · FRCentre National de la Recherche Scientifique · FRUniversity of Health Sciences Vientiane · LA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEpilepsy is a chronic condition treatable by cost-effective antiepileptic drugs (AEDs), but limited access to treatment was documented. The availability and affordability of good quality of AEDs play a significant role in access to good health care. This study aimed to assess the availability, affordability, and quality of long-term AEDs in Lao PDR.

methodA cross-sectional study was performed in both public and private drug supply chains in urban and rural areas in Lao PDR. Data on AEDs availability and price were obtained through drug suppliers. Affordability was estimated as the number of day wages the lowest-paid government employee must work to purchase a monthly treatment. Samples of AEDs were collected, and the quality of AEDs was assessed through Medicine Quality Assessment Reporting Guidelines.

resultsOut of 237 outlets visited, only 50 outlets (21.1% [95% CI 16.1-26.8]) had at least one AED available. The availability was significantly different between urban (24.9%) and rural areas (10.0%), SIGNIFICANCE: We quantified and qualified the various factors contributing to the high treatment gap in Lao PDR, adding to diagnostic issues (not assessed here). Availability remains very low and phenobarbital which is the most available and affordable AED was the worst in terms of quality. A drug policy addressing epilepsy treatment gap would reduce these barriers.

Indexed as

accessibilityantiepileptic drugsAsiaepilepsytreatment gap

Identifiers

PMID33336126
PMCPMC7733656
OpenAlexW3083444639

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.