ArticleBioactive materials2021
A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Full-laser-enabled clean hierarchical structuring and multifunctional synergy for high-performance in vivo 3D-printed implants.Materials today. Bio · 2026Article
- Calcium Phosphate Nanostructured Biocomposites with Applications in Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Review
- Enhanced biological performance of SrJournal of materials science. Materials in medicine · 2025Article
- Structural optimization of Sr/Zn-phosphate conversion coatings triggered by ions preloading on micro/nanostructured titanium surfaces for bacterial infection control and enhanced osteogenesis.Journal of nanobiotechnology · 2025Article
- Augmenting osteoporotic osseointegration through a temporal release nanocoating-based reversing dysregulated osteogenic microenvironment.Journal of orthopaedic translation · 2025Article
- Advanced surface modification techniques for titanium implants: a review of osteogenic and antibacterial strategies.Frontiers in bioengineering and biotechnology · 2025Review
- Antibacterial Properties and Biocompatibility of Multicomponent Titanium Oxides: A Review.Materials (Basel, Switzerland) · 2024Review
- Antibacterial coatings on orthopedic implants.Materials today. Bio · 2023Review
- Experimental study on repair of cartilage defects in the rabbits with GelMA-MSCs scaffold prepared by three-dimensional bioprinting.International journal of bioprinting · 2023Article
- Antimicrobial Properties of Plant Fibers.Molecules (Basel, Switzerland) · 2022Review
- Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection.Bioactive materials · 2022Article
- Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistantBioactive materials · 2022Article
- Material priority engineered metal-polyphenol networks: mechanism and platform for multifunctionalities.Journal of nanobiotechnology · 2022Article
- Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections: AnBioactive materials · 2022Article
- Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties.Bioactive materials · 2021Article
- Article
- 3D Printed Wesselsite Nanosheets Functionalized Scaffold Facilitates NIR-II Photothermal Therapy and Vascularized Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity.Nature communications · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles. However, ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc. As these incidents could easily introduce new microbial pathogens in/onto the implants. Herein, we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning, could effectively eradicate bacterial infection at various stages of implantation. Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating. Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating. Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model
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