Evidence map›Paper›PMID 33336110›Full record

ArticleBioactive materials2021

A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse.

Mengjie Xie, Junlang Li, Sichen Zhang, Dashuai Zhu, Xuan Mei, Zhenzhen Wang, Xiao Cheng, Zhenhua Li, Shaowei Wang, Ke Cheng

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. [Short-term exposure to gossypol causes reversible reproductive toxicity and nephrotoxicity in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mengjie XieThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Junlang LiDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.
Sichen ZhangDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.
Dashuai ZhuDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.
Xuan MeiDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.
Zhenzhen WangDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.
Xiao ChengDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.
Zhenhua LiDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.
Shaowei WangThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Ke ChengDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27607, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current contraceptive methods come with a number of drawbacks, including low efficacy, in the case of commercial contraceptive gels, and a reduction in the quality of sexual intercourse, in the case of condoms. Adding pharmacologically-active agents to contraceptive gels holds the potential to improve sexual experience, and hardbor safety and hygiene. In this study, we fabricated a Carbomer-based contraceptive gel consisting of three agents: tenofovir, gossypol acetate, and nitroglycerin (TGN), with pH adjusted to 4.5 (to be compatible with the vagina).

Indexed as

Anti-viralContraceptiveErection functionHydrogelLibido

Identifiers

PMID33336110
PMCPMC7724154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.