ArticleIBRO reports2020
The comorbidity conditions and polypharmacy in elderly patients with mental illness in a middle income country: a cross-sectional study⋆.
Article in IBRO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Burden of Illness in People with Alzheimer's Disease: A Systematic Review of Epidemiology, Comorbidities and Mortality.The journal of prevention of Alzheimer's disease · 2024Pooled it
- Efficacy and safety of DMB-I (latrepirdine) therapy in mild to moderate dementia in Alzheimer's disease: results of a multicenter, double-blind, randomized, placebo-controlled, clinical trial in three parallel groups.Scientific reports · 2026Trial
- Challenges in the End-of-Life Care for Patients With Severe Persistent Mental Illness: A Case Series.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- The association between Ankle Brachial Index (ABI) and cognitive impairment in geriatric patients at Dr Cipto Mangunkusumo Hospital Jakarta.BMC geriatrics · 2026Article
- Financial burden of older inpatients with multimorbidity in China: a cross-sectional study.Frontiers in public health · 2026Article
- Identifying factors and predicting mental health issues in polypharmacy elderly using machine learning: a study based on the English longitudinal study of aging.Frontiers in psychology · 2026Article
- Examining the Effect of Polypharmacy on Quality of Life and Frailty in Older Adults from the Perspective of Community-Based Rehabilitation.Healthcare (Basel, Switzerland) · 2025Article
- Potentially inappropriate medications for geriatric patients in Bahrain: prevalence, predictors, and implications for practice.BMC geriatrics · 2025Article
- Screening indicators to evaluate the clinical significance of drug-drug interactions in polypharmacy among older adults with psychiatric disorders: a delphi study.BMC psychiatry · 2024Article
- Cohort profile: Beijing Healthy Aging Cohort Study (BHACS).European journal of epidemiology · 2024Article
- Comorbidity among inpatients with dementia: a preliminary cross-sectional study in West China.Aging clinical and experimental research · 2023Article
- Clinical Practice Guidelines for the Assessment and Management of Elderly Presenting with Psychiatric Emergencies.Indian journal of psychiatry · 2023Article
- Sociodemographic characteristics and health-related quality of life of individuals undergoing antidepressant therapy.Scientific reports · 2022Article
- Social and health concerns of elderly women in rural area in Tirupur District, Tamil Nadu.Journal of family medicine and primary care · 2022Article
- Medication use problems among older adults at a primary care: A narrative of literature review.Aging medicine (Milton (N.S.W)) · 2022Review
- Effects of Changes in Multiple Chronic Conditions on Medical Costs among Older Adults in South Korea.Healthcare (Basel, Switzerland) · 2022Article
- The pattern of medication use, and determinants of the prevalence of polypharmacy among patients with a recent history of depressive disorder: results from the pars cohort study.BMC psychology · 2022Article
- Assessment of Polypharmacy, Drug Use Patterns, and Associated Factors at the Edna Adan University Hospital, Hargeisa, Somaliland.Journal of tropical medicine · 2022Article
- Introduction to the special issue on Neuroscience & lifestyle: From neurobiology to mental health.IBRO neuroscience reports · 2021Article
- Targeting neurotransmitter-mediated inflammatory mechanisms of psychiatric drugs to mitigate the double burden of multimorbidity and polypharmacy.Brain, behavior, & immunity - health · 2021Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMental disorders increase the risk factor for developing physical comorbidity conditions, such as cardiometabolic diseases. There is a high prevalence of multimorbidity and polypharmacy in the elderly population which hampers clinical response. Studies have shown that this positive correlation between the aging process and enhancement of physical comorbidities is especially high among older adults who live in low or middle income countries.
objectiveTo investigate the association between physical disease comorbidities and polypharmacy in older adults with a clinical diagnosis of Alzheimer's disease (AD), mild cognitive impairment (MCI) or major depressive disorder (MDD), living in a middle income country.
methodsCross-sectional study of community-dwelling elderly individuals who are cognitively healthy and those with AD, MCI, or MDD. The severity scale of the Charlson Comorbidity Index (CCI) was calculated to classify the severity of comorbidity condition. Logistic regression model (unadjusted and adjusted for age) were used to calculate odds ratios (OR) and 95 % confidence intervals (CI) for cardiometabolic comorbidity (hypertension, diabetes, dyslipidemia and overweight), and polypharmacy.
resultsAlthough there was not an increased risk of hypertension, diabetes, and obesity among the groups, elderly people with mental disorders presented higher odds for polypharmacy condition. Polypharmacy was significantly higher for all groups in comparison with cognitively healthy participants: AD (OR 22.00, 95 % CI 6.11-79.11), MDD (OR 14.73, 95 % CI 3.69-58.75) and MCI (OR 10.31, 95 % CI 2.44-43.59). Elderly patients with AD presented more severe comorbidities and higher risks for dyslipidemia.
conclusionElderly patients with depression, dementia and mild cognitive impairment have considerably higher odds for polypharmacy. People with dementia also have greater comorbidity severity than those who are cognitively healthy. In middle income countries, there is an urgent need to focus on promoting age-appropriate health approaches for the elderly with mental illness to prevent the development of aggravated cardiometabolic conditions and polypharmacy.
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