Evidence map›Paper›PMID 33336058›Full record

ArticleOpen medicine (Warsaw, Poland)2020

LncRNA NEAT1 promotes gastric cancer progression via miR-1294/AKT1 axis.

Dianchao Wu, Hui Li, Junfeng Wang, Hua Li, Qihai Xiao, Xiaofeng Zhao, Zhibin Huo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Recent advances of NEAT1-miRNA interactions in cancer.Acta biochimica et biophysica Sinica · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dianchao WuDepartment of Surgical Oncology, Xingtai People's Hospital, No.16, Hongxing Street, Xingtai, 054031, Hebei, China.
Hui LiDepartment of Surgical Oncology, Xingtai People's Hospital, No.16, Hongxing Street, Xingtai, 054031, Hebei, China.
Junfeng WangDepartment of Colorectal Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Hua LiDepartment of Surgical Oncology, Xingtai People's Hospital, No.16, Hongxing Street, Xingtai, 054031, Hebei, China.
Qihai XiaoDepartment of Surgical Oncology, Xingtai People's Hospital, No.16, Hongxing Street, Xingtai, 054031, Hebei, China.
Xiaofeng ZhaoDepartment of Surgical Oncology, Xingtai People's Hospital, No.16, Hongxing Street, Xingtai, 054031, Hebei, China.
Zhibin HuoDepartment of Surgical Oncology, Xingtai People's Hospital, No.16, Hongxing Street, Xingtai, 054031, Hebei, China.
Xingtai People's Hospital · CNHebei Medical University · CNTianjin Medical University Cancer Institute and Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) were reported to promote the development of gastric cancer (GC). Nuclear-enriched abundant transcript 1 (NEAT1) played a great role in diverse cancers, but the mechanism of NEAT1 in GC remains indistinct. NEAT1 and AKT1 were distinctly up-regulated and miR-1294 was down-regulated in GC tissues and cells. Cell proliferation and metastasis were refrained but apoptosis was promoted in GC cells after knockdown of NEAT1. NEAT1 negatively regulated miR-1294 expression, and the miR-1294 inhibitor reverted the si-NEAT1-induced effect on GC cells. NEAT1 modulated AKT1 expression through miR-1294, and the si-NEAT1-induced effect was relieved by AKT1. NEAT1 affected phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway via regulating miR-1294 and AKT1. NEAT1 could modulate cell proliferation, apoptosis, and metastasis in GC cells by regulating the PI3K/AKT/mTOR signaling pathway via the miR-1294/AKT1 axis, showing the great potential for NEAT1 as a valid biomarker in the progression and treatment of GC.

Indexed as

AKT1gastric cancermiR-1294NEAT1PI3K/AKT/mTOR pathway

Identifiers

PMID33336058
PMCPMC7718639
OpenAlexW3094059892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.