Evidence map›Paper›PMID 33336045›Full record

ArticleOpen medicine (Warsaw, Poland)2020

MiR-1225-5p acts as tumor suppressor in glioblastoma via targeting

Guo-Hua Wang, Liang-Yan Wang, Cui Zhang, Peng Zhang, Chuan-Hui Wang, Shuai Cheng

Open access · goldAbstract read
In one paragraph

Article in Open medicine (Warsaw, Poland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Guo-Hua WangDepartment of Neurosurgery, Sunshine Union Hospital of Shandong Province, No. 9000 Yingqian Street, Weifang, Shandong, 261000, People's Republic of China.
Liang-Yan WangDepartment of Ophthalmology, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong , 261000, People's Republic of China.
Cui ZhangDepartment of Neurosurgery, Sunshine Union Hospital of Shandong Province, No. 9000 Yingqian Street, Weifang, Shandong, 261000, People's Republic of China.
Peng ZhangDepartment of Neurosurgery, Sunshine Union Hospital of Shandong Province, No. 9000 Yingqian Street, Weifang, Shandong, 261000, People's Republic of China.
Chuan-Hui WangDepartment of Neurosurgery, Sunshine Union Hospital of Shandong Province, No. 9000 Yingqian Street, Weifang, Shandong, 261000, People's Republic of China.
Shuai ChengDepartment of Neurosurgery, Sunshine Union Hospital of Shandong Province, No. 9000 Yingqian Street, Weifang, Shandong, 261000, People's Republic of China.
Union Hospital · CNWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study attempted to research the molecular mechanism underlying the inhibitory role of miR-1225-5p in the malignant progression of glioblastoma. Bioinformatics analyses based on the gene expression omnibus (GEO) and Chinese glioma genome atlas (CGGA) databases showed that miR-1225-5p, as a favorable prognostic factor, was expressed at low levels in glioblastoma, and its expression was also related to WHO grade and age. The subsequent CCK-8 assay indicated that miR-1225-5p might prevent the malignant progression of glioblastoma, which was represented by that miR-1225-5p mimic reduced the viability of glioblastoma cells. Then, we predicted that

Indexed as

FNDC3BglioblastomamiR-1225-5pregulatetarget

Identifiers

PMID33336045
PMCPMC7712056
OpenAlexW3084485293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.