Evidence map›Paper›PMID 33336031›Full record

ReviewOpen medicine (Warsaw, Poland)2020

Hemoperitoneum caused by spontaneous rupture of hepatocellular carcinoma in noncirrhotic liver. A case report and systematic review.

Nicola Tartaglia, Alessandra Di Lascia, Pasquale Cianci, Alberto Fersini, Mario Pacilli, Giovanna Pavone, Antonio Ambrosi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Open medicine (Warsaw, Poland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Shock index and early warning score in liver cancer rupture shock.World journal of gastrointestinal surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nicola TartagliaDepartment of Medical and Surgical Sciences, University of Foggia, Luigi Pinto Street, No. 1, 71122, Foggia, Italy.
Alessandra Di LasciaDepartment of Medical and Surgical Sciences, University of Foggia, Luigi Pinto Street, No. 1, 71122, Foggia, Italy.
Pasquale CianciDepartment of Medical and Surgical Sciences, University of Foggia, Luigi Pinto Street, No. 1, 71122, Foggia, Italy.
Alberto FersiniDepartment of Medical and Surgical Sciences, University of Foggia, Luigi Pinto Street, No. 1, 71122, Foggia, Italy.
Mario PacilliDepartment of Medical and Surgical Sciences, University of Foggia, Luigi Pinto Street, No. 1, 71122, Foggia, Italy.
Giovanna PavoneDepartment of Medical and Surgical Sciences, University of Foggia, Luigi Pinto Street, No. 1, 71122, Foggia, Italy.
Antonio AmbrosiDepartment of Medical and Surgical Sciences, University of Foggia, Luigi Pinto Street, No. 1, 71122, Foggia, Italy.
University of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHepatocellular carcinoma (HCC) is the sixth most common cancer. Spontaneous rupture of HCC is an acute complication with a high mortality rate. The HCC principally arises in the background of chronic liver disease and cirrhosis of the liver. In the last few years, the rising incidence of HCC in noncirrhotic liver suggests the presence of other factors that may play a role in liver carcinogenesis.

methodsWe reviewed all cases treated at the University Surgical Department of Ospedali Riuniti of Foggia from 2009 to 2018. Only a single case of hemoperitoneum caused by spontaneous rupture of HCC in noncirrhotic liver was found. An extensive search of the relevant literature was carried out using MEDLINE, and a total of 58 published studies were screened from the sources listed.

conclusionsThe management of this devastating emergency should be carefully analyzed, with stabilization of vital signs as soon as possible. Patient with ruptured HCC and hemoperitoneum without a prior history of cirrhosis and viral infections benefited from the role of transcatheter arterial embolization (TAE) as the preliminary treatment in order to have a more precise diagnosis and an optimal stabilization of the patient. Delayed or staged hepatectomy after TAE represents the definitive treatment.

Indexed as

hemoperitoneumhepatocellular carcinomanoncirrhotic liverstaged hepatectomytranscatheter arterial embolization

Identifiers

PMID33336031
PMCPMC7712383
OpenAlexW3055207364

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.