ArticleAdvances in pediatric research2020
What proportion of the brain structural and functional abnormalities observed among children with fetal alcohol spectrum disorder is explained by their prenatal alcohol exposure and their other prenatal and postnatal risks?
Article in Advances in pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Neurodevelopmental impacts of unique postnatal adversity subgroups in children with prenatal alcohol exposure.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2026Article
- Decreased Cerebral Blood Flow in Young Children With Prenatal Alcohol Exposure.Biological psychiatry global open science · 2025Article
- The Impact of a Neurocollaborative Theraplay® Informed Intervention on the Presentations of Developmental Trauma and Attachment Difficulties in Adopted Children with Prenatal Alcohol Exposure: An Extended Case Study.Journal of child & adolescent trauma · 2025Article
- Parental factors predicting social deviance and psychological outcomes in offspring: Evidence from the Avon Longitudinal Study of Parents and Children (ALSPAC).Nordisk alkohol- & narkotikatidskrift : NAT · 2024Article
- Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development.Neuroscience and biobehavioral reviews · 2024Review
- Prenatal tobacco and alcohol exposure, white matter microstructure, and early language skills in toddlers from a South African birth cohort.Frontiers in integrative neuroscience · 2024Article
- Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.Frontiers in human neuroscience · 2024Article
- Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023Review
- Washington and Alaska statewide fetal alcohol spectrum disorder diagnostic clinical networks: Comparison of three decades of 4-Digit Code diagnostic outcomes and prenatal alcohol exposure histories.Advances in pediatric research · 2023Article
- Spectrum of MRI findings of foetal alcohol syndrome disorders-what we know and what we need to know!BJR open · 2023Article
- Arcuate fasciculus and pre-reading language development in children with prenatal alcohol exposure.Frontiers in neuroscience · 2023Article
- Trajectories of brain white matter development in young children with prenatal alcohol exposure.Human brain mapping · 2022Article
- Brain Iron and Mental Health Symptoms in Youth with and without Prenatal Alcohol Exposure.Nutrients · 2022Article
- Central white matter integrity alterations in 2-3-year-old children following prenatal alcohol exposure.Drug and alcohol dependence · 2021Article
- Epigenetic Impacts of Early Life Stress in Fetal Alcohol Spectrum Disorders Shape the Neurodevelopmental Continuum.Frontiers in molecular neuroscience · 2021Article
- Effects of prenatal alcohol exposure on neurobehavioural development and volume of rostral cingulate cortex subregions.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIndividuals with prenatal alcohol exposure (PAE) often present with a myriad of other prenatal (e.g. exposure to tobacco and other illicit drugs, poor prenatal care) and postnatal risk factors (e.g. multiple home placements, physical/sexual abuse, low socio-economic status)-all of which are likely contributing to their adverse outcomes.
methodsA comprehensive neuropsychological battery, coupled with magnetic resonance imaging, was administered to children with fetal alcohol spectrum disorders (FASD) in 2009. Study participants diagnosed with FASD by the University of Washington using the FASD 4-Digit Code were compared to typically-developing peers with no PAE. Data from this MRI study were used to explore the proportion of variance in brain structural and functional abnormalities explained by PAE and 14 other prenatal and postnatal risk factors.
resultsPAE was the dominant risk factor explaining the largest proportion of variance in regional brain size (total brain, frontal lobe, caudate, hippocampus and corpus callosum) and brain function (intellect, achievement, memory, language, executive-function, motor, adaptation, behavior-attention and mental health symptoms). Other prenatal and postnatal risk factors were 3 to 7-fold more prevalent than in the general population. Individually, each risk factor explained a statistically significant, but smaller proportion of variance in brain outcome compared to PAE. In combination, the proportion of variance explained by the presence of multiple prenatal and postnatal risks rivaled that of PAE.
conclusionA better understanding of the impact other prenatal and postnatal risk factors have on the neurodevelopmental outcomes of individuals with FASD can inform more effective prevention and intervention strategies.
Identifiers
33335991PMC7744001W3039176725What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.