Evidence map›Paper›PMID 33335899›Full record

ReviewFrontiers in cell and developmental biology2020

The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer.

Chaohua Jiang, Xiaohong Zeng, Renfeng Shan, Wu Wen, Jianfeng Li, Jinfeng Tan, Lei Li, Renhua Wan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
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  12. Circ_0001946 Promotes the Development of Acute Myeloid Leukemia by Upregulating PDL1Turkish journal of haematology : official journal of Turkish Society of Haematology · 2023
    Article
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  14. circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chaohua JiangDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Xiaohong ZengImaging Department, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Renfeng ShanDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Wu WenDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Jianfeng LiDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Jinfeng TanDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Lei LiDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Renhua WanDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Nanchang University · CNFirst Affiliated Hospital of Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are covalently closed circular structures without 5' caps and 3' tails, which are mainly formed from precursor mRNAs (pre-mRNAs) via back-splicing of exons. With the development of RNA sequencing and bioinformatic analysis, circRNAs were recently rediscovered and found to be widely expressed in the tree of life. Cerebellar degeneration-related protein 1 antisense RNA (CDR1as) is recognized as one of the most well-identified circRNAs. It contains over 70 miR-7 binding sites and can regulate gene activity by sponging miR-7. Increasing numbers of studies have recently demonstrated that CDR1as is abnormally expressed in many types of tumors, such as colorectal cancer, cholangiocarcinoma and osteosarcoma, and plays a vital role in the development of cancer. However, there are few reviews focusing on CDR1as and cancer. Hence, it is important to review and discuss the role of CDR1as in cancer. Here, we first review the main biological features of CDR1as. We then focus on the expression and roles of CDR1as in cancer. Finally, we summarize what is known on the role of CDR1as in cancer and discuss future prospects in this area of research.

Indexed as

biomarkercancerCDR1ascircular RNAmiRNA sponge

Identifiers

PMID33335899
PMCPMC7736612
OpenAlexW3107418345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.