Evidence map›Paper›PMID 33335852›Full record

ArticleFrontiers in oncology2020

A Novel Prognostic Model Incorporating Carcinoembryonic Antigen in 3-Week or Longer Postoperative Period for Stage III Colon Cancer: A Multicenter Retrospective Study.

Jin Fan, Yanlong Liu, Xin Cai, Jingwen Wang, Rui Guo, Yuan Ji, Chao Li, Ye Xu, Xinxiang Li, Chundong Zhang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Jin FanDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Yanlong LiuDepartment of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Xin CaiDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.
Jingwen WangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Rui GuoDepartment of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Yuan JiDepartment of Public Health Sciences, The University of Chicago, Chicago, IL, United States.
Chao LiDepartment of Radiation Oncology, Huashan Hospital Fudan University, Shanghai, China.
Ye XuDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.
Xinxiang LiDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.
Chundong ZhangDepartment of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Rui ZhangDepartment of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.
Ji ZhuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Sanjun CaiDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.
Fudan University Shanghai Cancer Center · CNChina Medical University · CNShanghai Medical College of Fudan University · CNChicago Department of Public Health · USFourth Affiliated Hospital of China Medical University · CNHuashan Hospital · CNThird Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic stratification of colon cancer using only the tumor-node-metastasis (TNM) stage has some limitations. We sought to increase the accuracy of stratifying patients with stage III colon cancer by constructing a prognostic model combining carcinoembryonic antigen (CEA) with TNM.

methodsWe retrospectively analyzed the data generated from stage III colon cancer patients who had early postoperative CEA measurement from 21 to 100 days after surgery from 2006 to 2017. CEA value was processed using restricted cubic splines (RCS) method. The prognostic model was developed using cox proportional hazards regression.

resultsThe time later than 20 days after surgery was optimal for measuring CEA, which was determined by comparing the prognostic value for preoperative and postoperative CEA (N = 2,049), and by evaluating the relationship between the hazard ratio (HR) and postoperative CEA measuring time. Postoperative CEA, T stage and N stage were selected into the final model, and the mean integrated-AUC (iAUC) was 0.78 with 1,000 × bootstrap resampling, which was higher than the model using only T and N stages (TN model; mean iAUC, 0.66). The net reclassification improvement (NRI) was 15% when compared with TN model. Patients could be divided into high and low risk groups by the model, and 3-year disease-free survival (DFS) were 53.7% and 87.0%, respectively (HR, 4.30; 95% CI, 2.65 to 6.96; P < 0.001). Similar results were found in the validation set.

conclusionsStage III colon cancer could be stratified more accurately using the new prognostic model combining postoperative CEA with T and N stage.

Indexed as

carcinoembryonic antigencolon cancerdisease-free survivalprognostic factorstumor-node-metastasis staging

Identifiers

PMID33335852
PMCPMC7736239
OpenAlexW3109934069

What OpenQuestion holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.