Evidence map›Paper›PMID 33335799›Full record

ArticleMolecular therapy. Nucleic acids2021

miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertension.

Giusy Russomanno, Kyeong Beom Jo, Vahitha B Abdul-Salam, Claire Morgan, Jens Endruschat, Ute Schaeper, Ahmed H Osman, Mai M Alzaydi, Martin R Wilkins, Beata Wojciak-Stothard

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. The pharmaco-epigenetics of hypertension: a focus on microRNA.Molecular and cellular biochemistry · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Non-coding RNAs regulating mitochondrial function in cardiovascular diseases.Journal of molecular medicine (Berlin, Germany) · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Review
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  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Giusy RussomannoNational Heart and Lung Institute, Imperial College London, London, UK.
Kyeong Beom JoNational Heart and Lung Institute, Imperial College London, London, UK.
Vahitha B Abdul-SalamNational Heart and Lung Institute, Imperial College London, London, UK.
Claire MorganNational Heart and Lung Institute, Imperial College London, London, UK.
Jens EndruschatSilence Therapeutics GmbH, Berlin, Germany.
Ute SchaeperSilence Therapeutics GmbH, Berlin, Germany.
Ahmed H OsmanNational Heart and Lung Institute, Imperial College London, London, UK.
Mai M AlzaydiNational Heart and Lung Institute, Imperial College London, London, UK.
Martin R WilkinsNational Heart and Lung Institute, Imperial College London, London, UK.
Beata Wojciak-StothardNational Heart and Lung Institute, Imperial College London, London, UK.
Imperial College London · GBSilence Therapeutics (Germany) · DEKing Abdulaziz City for Science and Technology · SAQueen Mary University of London · GBUniversity of Liverpool · GB

Funding

British Heart Foundation PG/16/4/31849
6 · The paper itself

Abstract

Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension (PAH) and act as an independent predictor of patient survival, but links between endothelial miR-150 and vascular dysfunction are not well understood. We studied the effects of endothelial miR-150 supplementation and inhibition in PAH mice and cells from patients with idiopathic PAH. The role of selected mediators of miR-150 identified by RNA sequencing was evaluated

Indexed as

cardiolipinendothelialfibrosismicroRNAmitochondriaproliferationPTPMT1pulmonary hypertensionremodellingvascular

Identifiers

PMID33335799
PMCPMC7733016
OpenAlexW3095367035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.