Evidence map›Paper›PMID 33335771›Full record

ArticleTranslational neuroscience2020

BDMC protects AD

Chenlin Xu, Zijian Xiao, Heng Wu, Guijuan Zhou, Duanqun He, Yunqian Chang, Yihui Li, Gang Wang, Ming Xie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chenlin XuThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Zijian XiaoThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Heng WuThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Guijuan ZhouThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Duanqun HeThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Yunqian ChangThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Yihui LiThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Gang WangDepartment of Rehabilitation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, People's Republic of China.
Ming XieThe First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
First Affiliated Hospital of University of South China · CNUniversity of South China · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is a common neurodegenerative disorder without any satisfactory therapeutic approaches. AD is mainly characterized by the deposition of β-amyloid protein (Aβ) and extensive neuronal cell death. Curcumin, with anti-oxidative stress (OS) and cell apoptosis properties, plays essential roles in AD. However, whether bisdemethoxycurcumin (BDMC), a derivative of curcumin, can exert a neuroprotective effect in AD remains to be elucidated.

methodsIn this study, SK-N-SH cells were used to establish an

resultsBDMC increased the cell survival, anti-OS ability, AMPK phosphorylation levels and SIRT1 in SK-N-SH cells treated with Aβ

conclusionThese results suggest that BDMC exerts a neuroprotective role on SK-N-SH cells

Indexed as

Alzheimer’s disease (AD)AMPKbisdemethoxycurcumin (BDMC)SIRT1

Identifiers

PMID33335771
PMCPMC7712110
OpenAlexW3088444601

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.