Evidence map›Paper›PMID 33335704›Full record

ArticleInterface focus2021

Towards blood flow in the virtual human: efficient self-coupling of HemeLB.

J W S McCullough, R A Richardson, A Patronis, R Halver, R Marshall, M Ruefenacht, B J N Wylie, T Odaker, M Wiedemann, B Lloyd and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Interface focus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 5 countries.

J W S McCulloughCentre for Computational Science, Department of Chemistry, University College London, London, UK.ORCID 0000-0002-9606-0408
R A RichardsonCentre for Computational Science, Department of Chemistry, University College London, London, UK.ORCID 0000-0002-9984-2720
A PatronisCentre for Computational Science, Department of Chemistry, University College London, London, UK.
R HalverJülich Supercomputing Centre, Forschungszentrum Jülich, Jülich, Germany.
R MarshallSimCenter, University of Tennessee at Chattanooga, Chattanooga, TN, USA.
M RuefenachtSimCenter, University of Tennessee at Chattanooga, Chattanooga, TN, USA.
B J N WylieJülich Supercomputing Centre, Forschungszentrum Jülich, Jülich, Germany.
T OdakerLeibniz Supercomputing Centre, Leibniz-Rechenzentrum (LRZ), Garching, Germany.
M WiedemannLeibniz Supercomputing Centre, Leibniz-Rechenzentrum (LRZ), Garching, Germany.ORCID 0000-0002-3366-0537
B LloydFoundation for Research on Information Technologies in Society (IT'IS), Zurich, Switzerland.
E NeufeldFoundation for Research on Information Technologies in Society (IT'IS), Zurich, Switzerland.
G SutmannJülich Supercomputing Centre, Forschungszentrum Jülich, Jülich, Germany.
A SkjellumSimCenter, University of Tennessee at Chattanooga, Chattanooga, TN, USA.
D KranzlmüllerLeibniz Supercomputing Centre, Leibniz-Rechenzentrum (LRZ), Garching, Germany.
P V CoveneyCentre for Computational Science, Department of Chemistry, University College London, London, UK.ORCID 0000-0002-8787-7256
Forschungszentrum Jülich · DEFaculty of 1000 (United Kingdom) · GBMax Planck Computing and Data Facility · DEUniversity of Tennessee at Chattanooga · USUniversity of Zurich · CH

Funding

Medical Research Council MR/L016311/1
6 · The paper itself

Abstract

Many scientific and medical researchers are working towards the creation of a virtual human-a personalized digital copy of an individual-that will assist in a patient's diagnosis, treatment and recovery. The complex nature of living systems means that the development of this remains a major challenge. We describe progress in enabling the HemeLB lattice Boltzmann code to simulate 3D macroscopic blood flow on a full human scale. Significant developments in memory management and load balancing allow near linear scaling performance of the code on hundreds of thousands of computer cores. Integral to the construction of a virtual human, we also outline the implementation of a self-coupling strategy for HemeLB. This allows simultaneous simulation of arterial and venous vascular trees based on human-specific geometries.

Indexed as

blood flow modellinghigh-performance computinglattice Boltzmann methodvirtual human

Identifiers

PMID33335704
PMCPMC7739917
OpenAlexW3111964610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.