ArticleComputational and structural biotechnology journal2020
Impact of crosslink heterogeneity on extracellular matrix mechanics and remodeling.
Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Beyond the Monolayer: Leveraging 3D Culture Systems to Decode Mechanisms of Drug Resistance and Therapeutic Vulnerabilities in Colorectal Cancer.Cancer medicine · 2026Review
- Percolation Forces in Lung Inflammation: Determining the Path to Emphysema or Fibrosis.Biomedicines · 2026Review
- Mechanical regulation of metabolism, epigenetics, and their interplay.npj biomedical innovations · 2026Review
- Tumor Development in Ulcerative Colitis: Perspectives From Biomechanical Characteristics.Development, growth & differentiation · 2025Review
- Enhanced extracellular matrix remodeling due to embedded spheroid fluidization.New journal of physics · 2025Article
- Article
- Vessel-On-A-Chip Coupled Proteomics Reveal Pressure-Overload-Induced Vascular Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Viscosity regulates cell spreading and cell-extracellular matrix interactions.The FEBS journal · 2025Article
- Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer.Bioengineering & translational medicine · 2025Review
- Tissue-dependent mechanosensing by cells derived from human tumors.npj biological physics and mechanics · 2025Article
- Mechanical signatures in cancer metastasis.npj biological physics and mechanics · 2025Review
- Article
- Comparative analysis of traction forces in normal and glaucomatous trabecular meshwork cells within a 3D, active fluid-structure interaction culture environment.Acta biomaterialia · 2024Article
- Machine learning-based approach for automated classification of cell and extracellular matrix using nanomechanical properties.Materials today. Bio · 2024Article
- Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells.Cells · 2024Review
- Fibre crosslinking drives the emergence of order in a three-dimensional dynamical network model.Royal Society open science · 2024Article
- Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility.Matrix biology : journal of the International Society for Matrix Biology · 2023Article
- Tunable Mesoscopic Collagen Island Architectures Modulate Stem Cell Behavior.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Unravelling cell migration: defining movement from the cell surface.Cell adhesion & migration · 2022Review
- Gradual Stress-Relaxation of Hydrogel Regulates Cell Spreading.International journal of molecular sciences · 2022Article
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1 author.
Funding
Abstract
Mechanical interactions between cells and the extracellular matrix (ECM) lead to the formation of biophysical cues, notably in the form of cell-generated tension, stiffness, and concentration profiles in the ECM. Fibrillar ECMs have nonlinear stiffnesses, linked to the reorientation of fibers under stress and strain, and nonelastic properties, resulting from the force-induced unbinding of transient bonds (crosslinks) that interconnect fibers. Mechanical forces generated by cells can lead to local ECM stiffening and densification. Cell tension is also propagated through the ECM network. The underlying factors that regulate the relative emergence of these signals are not well understood. Here, through computational simulations of 3D ECM fiber networks, we show that the composition of ECM crosslinks is a key determinant of the degree of densification and stiffening that can be achieved by cell-generated forces. This also regulates the sustainability of tensions propagated through the ECM. In particular, highly transient force-sensitive crosslinks promote nonelastic densification and rapid tension relaxation, whereas permanent crosslinks promote nonlinear stiffening and stable tension profiles. A heterogeneous population of crosslinks with different unbinding kinetics enables ECMs to exhibit accumulation, tension propagation, and stiffening simultaneously in response to mechanical interactions with cells.
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