ArticleComputational and structural biotechnology journal2020
A mathematical model for understanding synergistic regulations and paradoxical feedbacks in the shoot apical meristem.
Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Big data approaches to understanding gene regulatory networks in the shoot apical meristem andFrontiers in plant science · 2026Review
- Regulatory layers of robustness of CLAVATA-WUSCHEL feedback system in stem cell homeostasis.Frontiers in plant science · 2026Review
- The Role of CRABS CLAW Transcription Factor in Floral Organ Development in Plants.International journal of molecular sciences · 2025Review
- Functions and Regulation of HAM Family Genes in Meristems During Gametophyte and Sporophyte Generations.Plant, cell & environment · 2025Review
- Biophysical modelling as a tool for advancing plant science and engineering.Frontiers in plant science · 2025Review
- An updated model of shoot apical meristem regulation by ERECTA family and CLAVATA3 signaling pathways in Arabidopsis.Development (Cambridge, England) · 2024Article
- Initiation of aboveground organ primordia depends on combined action of auxin, ERECTA family genes, and PINOID.Plant physiology · 2022Article
- Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expression.Nucleic acids research · 2022Article
- Identification, visualization, statistical analysis and mathematical modeling of high-feedback loops in gene regulatory networks.BMC bioinformatics · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The shoot apical meristem (SAM) is the primary stem cell niche in plant shoots. Stem cells in the SAM are controlled by an intricate regulatory network, including negative feedback between WUSCHEL (WUS) and CLAVATA3 (CLV3). Recently, we identified a group of signals, Epidermal Patterning Factor-Like (EPFL) proteins, that are produced at the peripheral region and are important for SAM homeostasis. Here, we present a mathematical model for the SAM regulatory network. The model revealed that the SAM uses EPFL and signals such as HAIRY MERISTEM from the middle in a synergistic manner to constrain both
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.