Evidence map›Paper›PMID 33335677›Full record

ArticleACS medicinal chemistry letters2020

Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides.

Nicholas A Clanton, Shayne D Hastings, Griffin B Foultz, Julie A Contreras, Samantha S Yee, Hadi D Arman, April L Risinger, Doug E Frantz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicholas A ClantonDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Shayne D HastingsDepartment of Pharmacology and Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, United States.
Griffin B FoultzDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Julie A ContrerasDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Samantha S YeeDepartment of Pharmacology and Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, United States.
Hadi D ArmanDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
April L RisingerDepartment of Pharmacology and Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, United States.
Doug E FrantzDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
The University of Texas at San Antonio · USThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic steroids inspired by the naturally occurring taccalonolides. We demonstrate that these simplified analogs exhibit highly persistent antiproliferative properties similar to the taccalonolides and retain activity against resistant cancer cell lines that warrants further preclinical development.

Identifiers

PMID33335677
PMCPMC7734803
OpenAlexW3108386309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.